厦门大学化学化工学院：《有机化学》课程教学资源（课件讲稿，双语版）第十一章 羧酸衍生物（11.6-11.7）

酯缩合反应常用的碱 Ph3CNa/苯,醚 NaH/苯,醚 ③NaNH2/苯,甲苯,醚,液氨 a t-BuoK/t-BuOH 司 EtoNa/EtOH ■RL/醚

Organic Chemistry Organic Chemistry Xiamen Xiamen University University 酯缩合反应常用的碱 „ Ph 3CNa / 苯 醚 „ NaH / 苯 醚 „ NaNH 2 / 苯 甲苯 醚 液氨 „ t-BuOK /t-BuOH „ EtONa /EtOH „ RLi / 醚

Dieckmann condensation Intramolecular claisen condensation can be carried out with diesters, just as intramolecular aldol condensations can be carried out with diketones Called the Dieckmann condensation the reaction works best on 1, 6-diesters and 1,7 e diesters, and the products of such reactions are five-and six- membered 画ccc阝- keto esters

Organic Chemistry Organic Chemistry Xiamen Xiamen University University Dieckmann Condensation „ Intramolecular Claisen condensation can be carried out with diesters, just as intramolecular aldol condensations can be carried out with diketones. Called the Dieckmann condensation, the reaction works best on 1,6-diesters and 1,7- diesters, and the products of such reactions are five￾and six-membered cyclic β-keto esters