2) Capsule sizes Empty gelatin capsules are manufactured in various lengths, diameters, and capacities The size selected for use is determined by the amount of fill material to be encapsulated The density and compressibility of the fill will largely determine to what extent it may be packed into a capsule shell
2) Capsule sizes • Empty gelatin capsules are manufactured in various lengths, diameters, and capacities. • The size selected for use is determined by the amount of fill material to be encapsulated. • The density and compressibility of the fill will largely determine to what extent it may be packed into a capsule shell
3)Preparation of filled hard gelatin capsules Developing and preparing the formulation and selecting the size capsule Filling the capsule shells Capsule sealing(optional) Cleaning and polishing the filled capsules
3) Preparation of filled hard gelatin capsules • Developing and preparing the formulation and selecting the size capsule • Filling the capsule shells • Capsule sealing (optional) • Cleaning and polishing the filled capsules
4)Developing the formulation and selection of capsule size In developing a capsule formulation 九i he goal is to prepare a capsule ith accurate dosage good bioavailability ease of filling and production, stability, and elegance
4) Developing the formulation and selection of capsule size In developing a capsule formulation, the goal is to prepare a capsule with • accurate dosage, • good bioavailability, • ease of filling and production, stability, and elegance
In dry formulations, the active and inactive components must be blended thoroughly to ensure a uniform powder mix for the fill a diluent or filler actos microcrystalline cellulose and starch) may be added to the formulation to produce the proper capsule fill volume
• In dry formulations, the active and inactive components must be blended thoroughly to ensure a uniform powder mix for the fill. • A diluent or filler (lactose, microcrystalline cellulose and starch) may be added to the formulation to produce the proper capsule fill volume