流动镶嵌棋型是怎么提出来的? 流动镶嵌模型的含义是什么? 流动镶嵌模型提出后的30多年中 有什么新的进畏? 如何实现选择性跨膜运輪? 如何实现生物火分子的分选、运輪 和定位? MR YAN
THNMR YAN 流动镶嵌模型是怎么提出来的？ 流动镶嵌模型的含义是什么？ 流动镶嵌模型提出后的30多年中 有什么新的进展？ 如何实现选择性跨膜运输？ 如何实现生物大分子的分选、运输 和定位？
pesO ◇细胞膜的研究历史 Lipid Overton(1890s): nature of PM; (a Lpd naure Gortter and grendel(1925): The basis of membrane structure is a lipid bilayer Cell physiologists(1920s and 1930s) 192 The decrease in surface tensions ofPM might be explained by the proteins Du pein vson a H Davson and J Danielli (1935): o“ sandwich model” J D. Robertson(1959): The teM showing the trilaminar (eb Unt Robertson Toc appearance ofPM; Unit membrane mode on Flud mosac Singer and S.J. Singer and g Nicolson(1972 19E fluid-mosaic model; g) Membrane K.Simons et al(1997): 2000 ipid rafts model:
THNMR YAN 细胞膜的研究历史 ▪ Lipid Overton(1890s): nature of PM ; ▪ Gortter and Grendel(1925): The basis of membrane structure is a lipid bilayer ▪ Cell physiologists(1920s and 1930s) : The decrease in surface tensions of PM might be explained by the proteins . H.Davson and J.Danielli (1935): “sandwich model” ▪ J.D.Robertson(1959): The TEM showing:the trilaminar appearance of PM; Unit membrane model; ▪ S.J.Singer and G.Nicolson(1972): fluid -mosaic model; ▪ K.Simons et al(1997): lipid rafts model;
◇生物膜的流动镶嵌模型( fluid mosaic model) 产色色 生物膜是磷脂双分子层 嵌有蛋白质的二维流体 Central dogma of membrane biology 磷脂 糖脂 Figure 4. A brief history of the structure of the plasma face of most membrane proteins, as well as a small percent membrane. fa) A revised 1934 version of the dawson age of the phospholipids, contain short chains of sugars. 胆固醇和中性脂肪 D你你ir tend through the membrane to form protein-lined pore.(b The fluid-mosak model of membrane structure as ini mine acids (a From L F. Daidli, Colls mposed of hydrophobic proposed by Singer and Nicolson in 1972. Unlike previous reprntnf etth mission from S / Simser and G. LNirmls eis, the proteins penetrate into and through the lipid bi. Science 175720, 1972: copyright 1972 Layer. (c) A current representation of the plasma membrane the Adtuncewent ef Scienee. c From D Vort and 1 G Vot, Bo 如m比的p hemistry, 2nd el, copyright D 1995, Jaan Wwev 6 Sows, In Roprumfof by permission of llm wiley 6 Sons, inc)
THNMR YAN 生物膜的流动镶嵌模型(fluid mosaic model) 生物膜是磷脂双分子层 嵌有蛋白质的二维流体。 Central dogma of membrane biology 磷脂 糖脂 胆固醇和中性脂肪
磷脂 脂肪的基本成分(50%左右) 极性头部和非极性尾部 常有不饱和脂肪酸 糖脂 普遍存在,含量约在5%左右 ·神经细胞膜上含量高 红细胞表面的ABO血型糖脂 胆固醇 存在于真核细胞膜上 调节膜的流动性、稳定性和通透性 MR YAN
THNMR YAN 磷脂 • 脂肪的基本成分(50%左右) • 极性头部和非极性尾部 • 常有不饱和脂肪酸 糖脂 • 普遍存在，含量约在5%左右 • 神经细胞膜上含量高 • 红细胞表面的ABO血型糖脂 胆固醇 • 存在于真核细胞膜上 • 调节膜的流动性、稳定性和通透性