The characteristics of the biotech products C1. Biotech products are usually protein-based drugs 2. Mimic endogenous components with higher efficiency and lower side effects compare with small molecule drugs; 3. Intrinsic instability multifaceted metabolic o properties, and limited gastrointestinal absorption sually injections available 4. The biological half-life is usually very short results in very short duration
11 The characteristics of the biotech products • 1．Biotech products are usually protein-based drugs • 2．Mimic endogenous components with higher efficiency and lower side effects compare with small molecule drugs; • 3 ． Intrinsic instability, multifaceted metabolic properties, and limited gastrointestinal absorption; Usually injections available • 4．The biological half-life is usually very short, results in very short duration
Structure and the biological activity To alter the structure of ◇ a protein, as with heat, alkali, or acid so that some of its original properties, especiall its biological activity, 器 are diminished or eliminated f
12 To alter the structure of a protein, as with heat, alkali, or acid, so that some of its original properties, especially its biological activity, are diminished or eliminated Structure and the biological activity
secondary tertiary quaternary 二级结构 三级结构 四级结构 Scheme of the structure of proteins
Scheme of the structure of proteins secondary tertiary quaternary
u- spiral and阝- ◆ fold( secondary) ◇a螺旋与折叠 ial\co ◇ B7
14 α- spiral and β- fold (secondary ) α螺旋与β折叠
a ◇ The quaternary structure consists of two subunits of a protein 15
15 The quaternary structure consists of two subunits of a protein