Growth Hormone Deficiency 生长激素缺乏症 Xue Fan gu md phd Xinhua Hospital Shanghai jiao Tong University School of medicine
Growth Hormone Deficiency 生长激素缺乏症 Xue Fan Gu, MD, PhD Xinhua Hospital Shanghai Jiao Tong University School of Medicine
Short stature Below the 3rd percentile or -2SD than that of his or her peers Short stature has many causes the pathologic short stature should be suspected in children who have an abnormal growth velocity or who are significantly short for their family
Short stature • Below the 3rd percentile or －2SD than that of his or her peers • Short stature has many causes, the pathologic short stature should be suspected in children who have an abnormal growth velocity or who are significantly short for their family
Growth hormone Chemistry: 191 animo acid, 22-KDa protein Action To growth of the epiphyseal regions of the long bones, also via induce local IGF-I production in the epiphyseal plate at the both level of mRNa and protein. to promote the cell proliferation. a variety of metabolic effect, such as Anabolic action on protein metabolic, lipolysis, animo acid transport in diaphragm and heart. “ Dia ketogenic” action on large gh dose. The effects in normal aging and catabolic conditions are under investigation
Growth Hormone Chemistry：191 animo acid，22-KDa protein Action： • To growth of the epiphyseal regions of the long bones, also via induce local IGF-1 production in the epiphyseal plate at the both level of mRNA and protein. • to promote the cell proliferation. • A variety of metabolic effect, such as Anabolic action on protein metabolic, lipolysis, animo acid transport in diaphragm and heart. • “Diabetogenic” action on large GH dose. • The effects in normal aging and catabolic conditions are under investigation
SS GHRH 下丘脑一GH一IGF轴 门静脉 // GH GHAIGF-I Liver Bone muscle GH GHIIGF other tissues and organs IGF-I General circulation
下丘脑－GH－IGF轴
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