Innate Immunit (a) Self-nonself ( Danger CHaosa Necrosis (c)Surveillance Q00 Enzyme Degradation TRENDS immuno a Polly Matzinger
Innate Immunity Polly Matzinger
Adaptive immune response microbe Innate immunity Adaptive immun B lymphocytes 000oooo0 Epithelial i Antibodies 少 @⑨壤 Phagocytes Dendritic Effector T cells cells T lymphocytes Complement NK cells Hours Days 0 6 12 4 Time after infection
Adaptive immune response
Links between innate and adaptive immunity Adaptive immune respons Humoral immune response Cellular immune response IL-6 Th fragments (Th1 IFN Bacter Kill lL-12 Th Target Kill Intracellular killing Apoptosis MoM中 FN-& Chemokines Innate immune response
Links between innate and adaptive immunity
Cells of immune system Immune system Myeloid cells Lymphoid cells Granulocytic Monocytic T cells B cells NK cells Neutrophils Macrophages Helper cells Basophils Kupffer cells Suppressor cells Plasma cells Eosinophils Dendritic cells Cytotoxic cells
Cells of immune system
Stem Multipotent Committed Late precursors cells progenitors precursors and mature forms Common lymphoid Erythro genitor poletin Erythrocyte erythroblast Lymphopoiesis IL-6 →→→ Flt3L Megakaryoblast Platelet Myelopoiesis Thrombo poetic lL-11 Immature basophil hil →一O-区→ Common Immature eosinophil Eosinophil myeloid GM-CSF progenito Flt3L Monoblast Monocyte Flt3L → Dendritic ce‖l Myeloblast Neutrophil