Lymphocytes 1. Lymphocytes (except nK cells are wholly responsible for the specific immune recognition of pathogens, so they initiate adaptive immune responses 2. Lymphocytes are derived from bone-marrow stem cells 3. B lymphocytes develop in the bone marrow. T lymphocytes develop in the thymus. 3
Lymphocytes 1.Lymphocytes (except NK cells) are wholly responsible for the specific immune recognition of pathogens, so they initiate adaptive immune responses. 2.Lymphocytes are derived from bone-marrow stem cells. 3.B lymphocytes develop in the bone marrow. T lymphocytes develop in the thymus
Antigen recognition Effector functions Microbe NEutralization of microbe lymphocyte phagocytosis, complement Antibody activation Cytokines Activation of macrophages Inflammation Helper T Microbial antigen lymphocyte presented by antigen Activation presenting cell (proliferation and differentiation) of t and B lymphocytes Infected cell expressing microbial antigen Cytotoxic lymphocyt Killing of (CTL) infected cell Regulatory Suppression of T lymphocyte immune response Natural Killing of killer infected cell (NKcell