Special terms Bacteriostatic drugs Bacteriostatic drugs agents arrest the growth or replication of the microorganism, but cannot kill them Bactericidal drugs The agents which can kill the microorganisms are called bactericidal drugs but also can destroy them It should be noted that a drug may be bacteriostatic for one organism but bactericidal for another
Special terms Bacteriostatic drugs ◼ Bacteriostatic drugs agents arrest the growth or replication of the microorganism, but cannot kill them. Bactericidal drugs ◼ The agents which can kill the microorganisms are called bactericidal drugs. but also can destroy them. ◼ It should be noted that a drug may be bacteriostatic for one organism but bactericidal for another
Bactericidal vs bacteriostatic Control B Drug addition Bacteriostatic agent Bactericidal agent Time
Bactericidal vs bacteriostatic
Special terms Chemotherapy index(Cl) Cl is a term used to evaluate the safety of chemotherapeutic drugs, the value is LD50/ED50 or LD5/ED95 C= LD50/ED50 ■C|=LD5ED95
Special terms Chemotherapy index (CI) ◼ CI is a term used to evaluate the safety of chemotherapeutic drugs, the value is LD50/ED50 or LD5/ED95. ◼ CI= LD50/ED50 ◼ CI= LD5/ED95
Special terms Minimal inhibitory concentration(MIC Mic is the lowest concentration of antimicrobial agents that prevents visible growth in 18-24 hours incubation
Special terms Minimal inhibitory concentration (MIC) ◼ MIC is the lowest concentration of antimicrobial agents that prevents visible growth in18-24 hours incubation
Minimum bactericidal concentration (MBC)----The minimum concentration needs for kill 99.9% of testing microorganisms ■ If MBo≥32XMIC, it indicates that the microorganism has resistance to the drug
◼ Minimum Bactericidal Concentration (MBC)----The minimum concentration needs for kill 99.9% of testing microorganisms. ◼ If MBC≥32×MIC, it indicates that the microorganism has resistance to the drug