Antimicrobial Agents General Consideration Liming Zhou Department of pharmacology
Antimicrobial Agents General Consideration Liming Zhou Department of pharmacology
Contents Introduction Classification of antimicrobial drugs Special terms ■ Mechanism of action Resistance of antimicrobial agent
Contents ◼ Introduction ◼ Classification of antimicrobial drugs ◼ Special terms ◼ Mechanism of action ◼ Resistance of antimicrobial agent
Introduction Joseph Lister 1867-Father of Antisepsis. Introduced use of carbolic acid Paul Ehrlich 1908-10-first suggest using chemical compounds to treat microbial diseases Penicillium notatum inhibited the growth ofmold Alexander Fleming 1928-observed that the Staphylococcus aureus colonies-unable to purify the compound Gerhard Domagk 1935- Therapeutic value of sulfonamides against streptococcus and other organisms a Penicillin became available in quantities sufficient for clinical use in 1941
Introduction ◼ Joseph Lister 1867 - Father of Antisepsis. Introduced use of carbolic acid. ◼ Paul Ehrlich 1908-10 - first suggest using chemical compounds to treat microbial diseases． ◼ Alexander Fleming 1928 - observed that the mold Penicillium notatum inhibited the growth of Staphylococcus aureus colonies - unable to purify the compound. ◼ Gerhard Domagk 1935 - Therapeutic value of sulfonamides against streptococcus and other organisms. ◼ Penicillin became available in quantities sufficient for clinical use in 1941
ntroduction After that, Streptomycin, chloramphenicol, and tetracycline were discovered since then numerous classes of antimicorabial agents have been identified, and a lot of drugs are available for use today Antimicrobials are among the most commonly used drugs
Introduction ◼ After that ，Streptomycin, chloramphenicol, and tetracycline were discovered. Since then, numerous classes of antimicorabial agents have been identified, and a lot of drugs are available for use today. ◼ Antimicrobials are among the most commonly used drugs
Classification of antimicrobial drugs Antibacterial bacterial drugs Antiviral drugs ● Antifungal drugs
Classification of antimicrobial drugs ⚫ Antibacterial bacterial drugs ⚫ Antiviral drugs ⚫ Antifungal drugs