Host atient Antimicrobial effects Infectious Drug pathogen resistance Fig. 1 The relationship of Host-Drug-Pathogen in chem otherapy
Fig.1 The relationship of Host-Drug-Pathogen in chemotherapy
Antimicrobial Therapy Selective toxicity: bacterial infections provide differences in physiology that can be targeted for therapy Cell wall Protein synthesis: Ribosome Metabolism: antifolates DNA Synthesis: topoisomerase RNA Synthesis Membrane
Antimicrobial Therapy Selective toxicity: bacterial infections provide differences in physiology that can be targeted for therapy Cell wall Protein synthesis: Ribosome Metabolism: antifolates DNA synthesis: topoisomerase RNA synthesis Membrane
Antibacterial agent(抗菌药) a Antibacterial agent can be defined as substances from microorganisms(bacteria, fungi or synthesized substance that produce bacteriostatic or bactericidal effects Antibiotics(抗生素) can be defined as substances from microorganisms(bacteria, fungi) that produce bacteriostatic or bactericidal effects
Antibacterial agent(抗菌药） ◼ Antibacterial agent can be defined as substances from microorganisms (bacteria, fungi) or synthesized substance that produce bacteriostatic or bactericidal effects. ◼ Antibiotics(抗生素） can be defined as substances from microorganisms (bacteria, fungi) that produce bacteriostatic or bactericidal effects．
Special terms Antimicrobial spectrum Antimicrobial spectrum of a drug means the species of microorganisms that the drug can inhibit or kill 1. Narrow spectrum The agents act against a single or limited group of microorganisms, for example, isoniazid is active only against mycobacteria
Special terms Antimicrobial spectrum Antimicrobial spectrum of a drug means the species of microorganisms that the drug can inhibit or kill. 1.Narrow spectrum The agents act against a single or limited group of microorganisms, for example, isoniazid is active only against mycobacteria
Special terms Broad spectrum The agent affect a wide variety of microbial species and are referred to as broad spectrum antibiotics For example, tetracyclines and chloramphenicol a Using broad spectrum antibiotics interfere the nature of the normal bacterial flora and can precipitate a superinfection of an organism
Special terms Broad spectrum ◼ The agent affect a wide variety of microbial species and are referred to as broad spectrum antibiotics. ◼ For example, tetracyclines and chloramphenicol. ◼ Using broad spectrum antibiotics interfere the nature of the normal bacterial flora and can precipitate a superinfection of an organism