e Modern insulins Nov。 Rapid DIABETES Product CARE Glucagon-like peptide-1 Victor portfolio ● Human insulins Insulatard Actrapid represent s ot a produsts are a Diabetes devices HexPen ovoPen*s NovoPen eCHoer InnoLet available in all markets. some lifferent product brand nan nde e Oral antidiabetic agents some markets. Please contact relevant local Novo Nordisk affiliates for further informati OBESITY Saxenda' HAEMOPHILIA [=〔 HUMAN GROWTH HORMONE Norditropin
Product portfolio This product portfolio overview represents Novo Nordisk’s global portfolio. Not all products are available in all markets. Some products may be available under different product brand names in some markets. Please contact relevant local Novo Nordisk affiliates for further information. DIABETES CARE FlexTouch® FlexPen® NovoPen® 5 NovoPen® 4 NovoPen Echo® InnoLet® NovoNorm® PrandiMet® Victoza® Insulatard® Actrapid® Mixtard® 30 Levemir® NovoRapid® NovoMix® 30 NovoMix® 50 NovoMix® 70 New generation insulins Modern insulins Glucagon-like peptide - 1 Human insulins Diabetes devices & accessories OBESITY Tresiba® Ryzodeg® Xultophy® Saxenda® Oral antidiabetic agents Norditropin® Norditropin FlexPro® Norditropin NordiFlex® NordiPen PenMate® SimpleXx® NordiLet® HAEMOPHILIA HUMAN GROWTH HORMONE Novo Seven® Novo Eight® Novo Thirteen®
Novo Nordisk's vision and strategy STRATEGIC PRIORITIES CORE CAPABILITIES Engineering Efficient Planning and Expand leadership in DIABETES production of nd d proteins position in protein-based new products Driving change to defeat diabetes Establish presence in and other serious OBESITY chronic conditions Pursue leadership in HAEMOPHILIA Expand leadership in GIROWTH DISORDERS Novo Nordisk Way
Novo Nordisk’s vision and strategy Expand leadership in DIABETES Establish presence in OBESITY Expand leadership in GROWTH DISORDERS Pursue leadership in HAEMOPHILIA Engineering, formulating, developing and delivering protein-based treatments Deep disease understanding Efficient large-scale production of proteins Planning and executing global launches of new products Building and maintaining a leading position in emerging markets STRATEGIC PRIORITIES CORE CAPABILITIES Driving change to defeat diabetes and other serious chronic conditions Novo Nordisk Way
Presentation outline Novo nordisk Why engineer peptides (and proteins) Type 2 diabetes The discovery of the first once daily gLp-1 Further engineering of long acting GLP-1 PLEASE INTERRUPT AND ASK!
• Novo Nordisk • Why engineer peptides (and proteins) • Type 2 diabetes • The discovery of the first once daily GLP-1 • Further engineering of long acting GLP-1 Presentation Outline 8 PLEASE INTERRUPT AND ASK!
More Biologics are becoming Block Buster 's he100 Hing drugs in 2015 Indication/drug type 2015 sales(sm) Autoimmune(various) 14012 Best selling drugs Gilead 13864 7327 2003:0 biologics in top 20 2009:7 biologics in top 20 2015: 7 biologics in top 10 Januvia/Janumet Merck & Co Revlimid (various op 100 biggest selling Astrazeneca pharmaceutical products Neulasta Glivec generated combined sales of Spiriva Boehringer Ingelheim CO $265 billion in 2015 Tecfidera Multiple 13638 Atripla ) Nordisk
More Biologics are becoming Block Buster´ s 9 Best selling drugs: 2003: 0 biologics in top 20 2009: 7 biologics in top 20 2015: 7 biologics in top 10 Top 100 biggest selling pharmaceutical products generated combined sales of $265 billion in 2015
Trends in clinical development Number of Therapeutic Peptides in Clinical Study has nearly doubled since the 1990 Status of 3 34 therapeutic peptides 149 terminated peptides entering clinical trials 18 131 in development 16 o41 at phase 1 B14 12 ●72 in phase2 o16 in phase 3 8 54 approved by at least 2 one agency 0.2 3 40s 50's 60s 70s 80s 90s 00-08 Source: Tufts Center for the study of Drug Development 2010 http://www.peptidetherapeuticsorg/ptf_reporT_sUmmaRy_2010.pdf
Slide no 10 Trends in clinical development Status of 334 therapeutic peptides: 149 terminated: 131 in development: •41 at phase 1 •72 in phase 2 •16 in phase 3 54 approved by at least one agency Source: Tufts Center for the study of Drug Development 2010: http://www.peptidetherapeutics.org/PTF_report_summary_2010.pdf Number of Therapeutic Peptides in Clinical Study has nearly doubled since the 1990 peptides entering clinical trials