Antigenen sablized membrane--cromolyr muscle muscle contraction mast Histamine vascular cells SRS-A vascular leakage mucus Hyper-secretion gland edema Trachea Bronchi 一Ach aIrway narrowing inflammation Corticosteroid exercises M-R antagonist irritants theophylline Sympathomimetic agents
mast cells Histamine SRS-A 5-HT Trachea Bronchi muscle vascular mucus gland muscle contraction vascular leakage Hyper-secretion edema airway narrowing inflammation exercises irritants Antigenen Ach M-R antagonist Sympathomimetic agents Corticosteroids theophylline sablized membrane--cromolyn
Short-term pharmacological relief bronchodilators(promote airway smooth muscle relaxation increased airway caliber 阝— adrenoceptor agonists Theophylline Antimuscarinic drugs
Short-term pharmacological relief bronchodilators (promote airway smooth muscle relaxation increased airway caliber ) ß—adrenoceptor agonists Theophylline Antimuscarinic drugs
Long-term(Antinflammatory pharmacological management Inhaled corticosteroids Leukotriene pathway inhibitors Inhibitors of mast cell degranulation (e.g., cromolyn色甘酸
Long-term(Antiinflammatory) pharmacological management: Inhaled corticosteroids Leukotriene pathway inhibitors Inhibitors of mast cell degranulation (e.g.,cromolyn色甘酸)
sympathomimetic drugs ByR→→→ smooth muscle →CAMP↑→→ dilation 2R→→ mast cells-→ → mediators release↓ aR→→→ microvascular constricting→→ edema↓
sympathomimetic drugs β2 -R→→smooth muscle→ → cAMP↑ →→dilation β2 -R →→ mast cells→ →mediators release ↓ α -R→ →microvascular constricting →→ edema↓
CH3 CH cH一CH2一NH一CH H2-NH一c一CH3 CH OH CH Isoproterenol Terbutaline H20H cH一CHNH一CH cH一CH2-NH-c-cH OH C2H5 OH CH Isoetharine buterol (salbutamol) CH,OH cH一cH2一NH一cH cH一CH2-NH一cH c OH (CH24 Metaproterenol Salmeterol CH 0 CH (CH2I2 CH