Pathogenesis Ectopic transplantation theory(异位种植学说) (Blood or Lymphatic Vessel Spread) Endometrial tissues have been found in lymphatic nodes and pelvic venous blood vessels Presence of endometriosis in organs distal to pelvis e.g. lung and muscle or skin of the extremities( k)
• Endometrial tissues have been found in lymphatic nodes and pelvic venous blood vessels. • Presence of endometriosis in organs distal to pelvis e.g. lung and muscle or skin of the extremities (四肢). Pathogenesis Ectopic transplantation theory (异位种植学说） (Blood or Lymphatic Vessel Spread)
Pathogenesis Metaplasia of Coelomic Epithelium(体腔上皮化生学说) Serosa(浆膜) and peritoneum(腹膜) originate from e multipotent coelomic epithelium Predisposing factors ● Genetic influences Incidence is 6. 9% in first-grade relatives of patients with endometriosis compared with 1%o in a control group Incidence is 75% if one of the twin sisters has endometriosis Immune deficiency e Monkeys with spontaneous endometriosis were found to have lowered cell-mediated response to autologous(自体的) endometrial tissue
Metaplasia of Coelomic Epithelium(体腔上皮化生学说) Serosa (浆膜) and peritoneum (腹膜) originate from multipotent coelomic epithelium Predisposing factors Genetic influences Incidence is 6.9% in first-grade relatives of patients with endometriosis compared with 1% in a control group. Incidence is 75% if one of the twin sisters has endometriosis. Immune deficiency Monkeys with spontaneous endometriosis were found to have lowered cell-mediated response to autologous (自体的) endometrial tissue. Pathogenesis
Pathology The basic pathological change of endometriosis is that the ectopic endometrium periodically bleeds in response to changes in ovarian sex hormones resulting in growth of surrounding fibrous tissue and formation of cysts( endometrioma/子宫内膜异位囊肿 and/or adhesion
Pathology The basic pathological change of endometriosis is that the ectopic endometrium periodically bleeds in response to changes in ovarian sex hormones resulting in growth of surrounding fibrous tissue and formation of cysts (endometrioma/子宫内膜异位囊肿) and/or adhesion