上商充通大 Shanghai Jiao Tong University Mechanism of action
Shanghai Jiao Tong University Mechanism of action
上游充通大学 CLASSES OF ANTIBIOTICS Shanghai Jiao Tong University Inhibitors of cell wall synthesis Agents that interfere with cell membrane permeability Inhibitors of nucleic acid synthesis or activity Inhibitors of protein synthesis Inhibitors of bacterial metabolism
Shanghai Jiao Tong University Inhibitors of cell wall synthesis Agents that interfere with cell membrane permeability Inhibitors of nucleic acid synthesis or activity Inhibitors of protein synthesis Inhibitors of bacterial metabolism … CLASSES OF ANTIBIOTICS
h 上游充通大学 Antimicrobial site of action Shanghai Jiao Tong University DNA gyrase Cell wall synthesis DN A-directed RNA polymerase DNA THFA mRNA- 米 Rosomes Protein synthesis DHFA 30S 30S (30S inhib itors) Folic acid metabolism Periplasmic space Protein synthesis (50S inhibitors) PABA Cell membrane
Shanghai Jiao Tong University Antimicrobial site of action
Cell wall synthesis Beta-lactams Vancomycin DNA replication Isoniazid Quinolones Ethambutol Metronidazole Cycloserine Ethionamide Bacitracin RNA synthesis Polymyxin DNA Rifampin xexcXocooc...c Rifabutin mRNA> Ribosomes 888 Antimetabolites Protein synthesis Sulfonamides (50S ribosome) Dapsone Protein synthesis Chloramphenicol Trimethoprim (30S ribosomes) Macrolides Para-aminosalicylic acid Aminoglycosides Clindamycin Tetracyclines Streptogramins Oxazolidinone FIGURE 20-1.Basic sites of antibiotic activity
Shanghai Jiao Tong University
h 上游充通大学 Cell Wall Synthesis Inhibitors 后 Shanghai Jiao Tong University ©Penicillins青霉素 ©Cephalosporins B-lactam antibiotics 头孢菌素 ©Vancomycin万古霉素 B-Lactam ring 圈Bacitracin杆菌肽 H H HS、 CH3 R-N一C一 CHa N COOH
Shanghai Jiao Tong Universit C y ell Wall Synthesis Inhibitors Penicillins青霉素 Cephalosporins 头孢菌素 Vancomycin万古霉素 Bacitracin杆菌肽 β-lactam antibiotics