Factors influencing immunogenicity A. Contribution of the Immunogen 3. Size - there is not absolute size above which a substance will be immunogenic. In general the larger the molecule the more immunogenic it is likely to be high molecular weight: >6000 Da
Factors influencing immunogenicity A. Contribution of the Immunogen 3. Size - There is not absolute size above which a substance will be immunogenic. In general, the larger the molecule the more immunogenic it is likely to be. high molecular weight：>6000 Da
Factors influencing immunogenicity 4. Chemical Complexity-an increase in the chemical complexity of a compound is accompanied by an increase in its immunogenicity. thus copolymers of several amino acids such as polyglutamic, alanine tend to be highly immunogenic primary structure: amino acid sequence secondary structure: backbone of the polypeptide chain tertiary structure: three-dimensional configuration quaternary structure more than one protein subunit
Factors influencing immunogenicity 4.Chemical Complexity- an increase in the chemical complexity of a compound is accompanied by an increase in its immunogenicity. Thus copolymers of several amino acids, such as polyglutamic, alanine, tend to be highly immunogenic. primary structure: amino acid sequence secondary structure :backbone of the polypeptide chain tertiary structure: three-dimensional configuration quaternary structure: more than one protein subunit