Antigenicity and specificity 米 specificity 1. Antigenic determinant(epitope) the portion of the antigen that binds specifically with the binding site of an antibody or a receptor on a lymphocyte the size of an epitope is approximately equivalent to 5-7 amino acids
Antigenicity and specificity * specificity 1. Antigenic determinant (epitope) - the portion of the antigen that binds specifically with the binding site of an antibody or a receptor on a lymphocyte. - the size of an epitope is approximately equivalent to 5-7 amino acids
Antigenicity and specificity description example One epitope haptens Many epitopes of the same polysaccharides specificity Many epitopes of proteins different specificity Reprensentation of some possible antigenic structures
Antigenicity and specificity description example One epitope haptens Many epitopes of the same specificity polysaccharides Many epitopes of different specificity proteins Reprensentation of some possible antigenic structures
Antigenicity and specificity 2. structure of epitopes conformational determinant sequential or linear determinant c02 Intact prot 0 B cell epitope: 1, 2. linear epitopes; 3. conformational epitop o Tcell epitope: 4, 5. linear epitopes (presented by MHC molecules)
Antigenicity and specificity 2.structure of epitopes conformational determinant sequential or linear determinant
3. Epitopes recognized by B cells Epitopes recognized by T cells B cell epitope Antigenic peptide Degradation T cell epitope T cell epitope Natural protein B cell epitope and T cell epitope 76
3. Epitopes recognized by B cells Epitopes recognized by T cells B cell epitope T cell epitope Degradation Natural protein Antigenic peptide T cell epitope B cell epitope and T cell epitope
4 5 2 degradation 02 Intact protein protein fragments O B cell epitope: 1, 2. linear epitopes; 3. conformational epitope T cell epitope: 4, 5. linear epitopes(presented by MHC molecules) T and b cell epitopes in a protein antigen y
Antigen T and B cell epitopes in a protein antigen