The target of transplant rejection Major Histocompatibility Complex (MHC抗原) also referred as to human Leukocyte Antigen(HLA抗原) Characteristics: high variety
The target of transplant rejection Major Histocompatibility Complex (MHC抗原) also referred as to Human Leukocyte Antigen (HLA抗原) Characteristics: high variety
Classification of Transplant Rejection Hyperacute rejection(超急性排异反应) Occurs within minutes to a few hours after transplantation > Acute rejection(急性排异反应) Occurs within days, weeks, months even years. Chronic rejection(慢性排异反应) Occurs in months to years
Classification of Transplant Rejection ➢Hyperacute Rejection(超急性排异反应) Occurs within minutes to a few hours after transplantation ➢Acute Rejection (急性排异反应) Occurs within days, weeks, months even years. ➢Chronic Rejection (慢性排异反应) Occurs in months to years
Hyperacute rejection Antibody-mediated (type ID) hy persensitivity circulating antibodies rapidly bind to endothelium of the grafted organ complement fixation and vascular thrombosis
Hyperacute rejection Antibody-mediated (type II) hypersensitivity circulating antibodies rapidly bind to endothelium of the grafted organ complement fixation and vascular thrombosis
Antidonor antibodies are present in the circulation of the host before transplant: multiparous women who have anti-HLA antibodies against paternal antigens shed from a fetus exposure to foreign HLa from prior blood transfusions host who has already rejected an organ transplant
Antidonor antibodies are present in the circulation of the host before transplant: ▪multiparous women who have anti-HLA antibodies against paternal antigens shed from a fetus. ▪exposure to foreign HLA from prior blood transfusions. ▪host who has already rejected an organ transplant
Morphology >Gross: swelling, cyanotic. > Microscope: arteritis and arteriolitis vessel thrombosis ischemic necrosis
Morphology ➢Gross: swelling, cyanotic. ➢Microscope: arteritis and arteriolitis vessel thrombosis ischemic necrosis