复旦大学：《肿瘤学概论 Basics of Clinical Oncology》课程PPT教学课件（英文）分子靶向治疗原则——现状与未来 Principles of Molecularly Targeted Therapy_Present and Future

Fudan University Shanghai cancer Center 《 Basic clinical oncology》 Principles of Molecularly Targeted Therapy: Present and Future Fudan University Cancer center Guo Ye. MD Arrrr 复旦大学上海医学院肿瘤学糸

1 复旦大学上海医学院肿瘤学系 Fudan University Shanghai Cancer Center 《Basic Clinical Oncology》 Principles of Molecularly Targeted Therapy: Present and Future Fudan University Cancer Center Guo Ye, MD

Fudan University shanghai cancer center Self-introduction Name: Guo Ye, MD(Patrick Guo Institute: Fudan University Shanghai Cancer Center Major: Medical Oncologist Specialty: lymphoma, Head neck cancer Overseas training: Department of Hematology-Oncology, National University Hospital, Singapore( Clinical Fellowship) E-mailaddresspattrickguo@gmail.com 复旦大学上海医学院肿瘤学糸

Fudan University Shanghai Cancer Center 复旦大学上海医学院肿瘤学系 2 Self-introduction ▪ Name: Guo Ye, MD (Patrick Guo) ▪ Institute: Fudan University Shanghai Cancer Center ▪ Major: Medical Oncologist ▪ Specialty: lymphoma, Head & neck cancer ▪ Overseas training: Department of Hematology-Oncology, National University Hospital, Singapore (Clinical Fellowship) ▪ E-mail address: pattrickguo@gmail.com Fudan University Shanghai Cancer Center

Fudan University Shanghai cancer Center Mainstay Treatment Strategies Surgery Radiotherapy Chemotherapy Targeted therapy -- personalized therapy 复旦大学上海医学院肿瘤学糸

Fudan University Shanghai Cancer Center 复旦大学上海医学院肿瘤学系 3 Mainstay Treatment Strategies ▪ Surgery ▪ Radiotherapy ▪ Chemotherapy ▪ Targeted therapy --- personalized therapy

Fudan University Shanghai cancer Center Disadvantages of Cytotoxic Chemotherapy Non-selective Substantial and cumulative side effects Immunosuppressive Maintenance usually Impossible ■| convenient Mostly intravenous Frequent hospital visits 复旦大学上海医学院肿瘤学糸

Fudan University Shanghai Cancer Center 复旦大学上海医学院肿瘤学系 4 Disadvantages of Cytotoxic Chemotherapy ▪ Non-selective ▪ Substantial and cumulative side effects ▪ Immunosuppressive ▪ Maintenance usually impossible ▪ Inconvenient ﹣Mostly intravenous ﹣Frequent hospital visits

Fudan University Shanghai cancer Center Hallmarks of cancer Sustaining proliferative signaling Resisting Evading growth cell death suppressors Inducing Activating invasion oogenesiS and metastasis Enabling replicative mmortality 复旦大学上海医学院肿瘤学糸 Hanahan D, et al. Cell. 2000: 100: 57

Fudan University Shanghai Cancer Center 复旦大学上海医学院肿瘤学系 5 Hallmarks of Cancer Hanahan D, et al. Cell. 2000;100:57