motor steam inlet H contro steam ⊥ reservoir outlet exhaust Penicillium outlet inlet cold water outlet cold wate jacket paddle wheel emperature recorder and cold water pump control cold water inlet air inlet AIR FILTER harvest line
Because of its cheapness, efficacy, and remarkable lack of toxicity(except for acutely allergic patients). Peniciline g remains a remarkably useful agent for treatment of disease caused by susceptible microorganisms It is the drug of choice for more infections than any other antibiotics. " Fist is best The disadvantages of fermentation-Derived penicillins (Penicillin G) I Narrower in antibacterial spectrum, active for g-ponly poor active for G-N 2. Can not be oral administrated, just for injection. 3. allergic action 4. susceptible to acid and penicillinase 5.produces Penicllins-resistant bacteria
Because of its cheapness, efficacy, and remarkable lack of toxicity (except for acutely allergic patients). Peniciline G remains a remarkably useful agent for treatment of disease caused by susceptible microorganisms. It is the drug of choice for more infections than any other antibiotics. “ Fist is best” The disadvantages of Fermentation-Derived Penicillins (Penicillin G) 1.Narrower in antibacterial spectrum, active for G-P only, poor active for G-N 2.Can not be oral administrated , just for injection. 3.allergic action 4.susceptible to acid and Penicillinase 5.produces Penicllins-resistant bacteria
NH2 R NH pH=4 C-CH-COOH+RCONHCH2-CHO RT COOH SH 青霉胺 青霉醛 COOH R NH R COOH COOH R COOH 青霉二胺
青霉胺 青霉醛 N S O H COOH R NH O CH3 C CH3 CH COOH NH2 SH RCONHCH2 CHO pH=4 R.T N S O H COOH NH R O N S H COOH O N O R N N S COOH COOH R 青霉二胺
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青霉酸
Semi-Synthetic Penicillins HH R-C-NH H COOH Penicilling R= (青霉素G) Fermentation Derivater of penicillium Penicillin X R- 青霉素X) Fermentation derivate of penicillium HO
Semi- Synthetic Penicillins N S O C NH O H H H COOH R Penicillin G (青霉素 G) R= Fermentation Derivater of Penicillium Penicillin X (青霉素 X) R= HO Fermentation Derivater of Penicillium