Thyroid hormone-intracorporal process o easy to absorb using po and the oral absorption rate of T3 and Ta are 50%w 75% and 75%w 90% respectively oThe rate of plasma protein combining is 99%, and the protein binding of T3 is less than the T4, the role of t3 is more potent than Ta with a half-life for 2 days, T4 is slow and weak with a half-life for 5 days
Thyroid hormone—intracorporal process Easy to absorb using Po and the oral absorption rate of T3 and T4 are 50% ~ 75% and 75% ~ 90% respectively. The rate of plasma protein combining is 99%, and the protein binding of T3 is less than the T4 , the role of T3 is more potent than T4 with a half-life for 2 days, T4 is slow and weak with a half-life for 5 days
Thyroid hormone-intracorporal process o The liver is the major site of nondeiodinative degradation, T4 and T3 are conjugated with glucuronic and sulfuric acids and excreted in the rena OAs it can go through the placenta and breast milk pregnancy and lactation women should be cautious
Thyroid hormone—intracorporal process The liver is the major site of nondeiodinative degradation, T4 and T3 are conjugated with glucuronic and sulfuric acids and excreted in the renal As it can go through the placenta and breast milk, pregnancy and lactation women should be cautious
Thyroid hormone--intracorporal process Tab 1 Summary of thyroid hormone kinetics kinetics daily production(ug) 70≈90 15~30 fractional turnover per day ( % 10 60 metabolic clearance per day l/d 24 amount bound (%) 99.96 996 volume of distribution (l) 10 40 serum level (total)( ug/dL) 4.5~11 60~180 serum level(free)(ng/dL) 0.7~186 0.2~0.52 half-life(biologic)(d) 7 biological potency orarabaarption(% 80
kinetics T４ T3 daily production (µg) 70～90 15～30 fractional turnover per day (%) 10 60 metabolic clearance per day (L/d) 1.1 24 amount bound (％) 99.96 99.6 volume of distribution (Ｌ) 10 40 serum level(total) ( µg/dL) 4.5～11 60～180 serum level(free) (ng/dL) 0.7～1.86 0.2～0.52 half-life(biologic) (d) 7 1 biological potency 1 4 oral absorption (%) 80 95 Tab 1 Summary of thyroid hormone kinetics
Thyroid hormone--Pharmacological e斤 fects Growth and Development hypothyroidism: child→ cretinism(呆小症) adut→ myxedema(黏液水肿 o Calorigenic Effects Increase the basal metabolic rate and excessive production of heat Improve the sensitivity of sympathetic-The susceptibility of adrenal system
Thyroid hormone—Pharmacological effects Growth and Development hypothyroidism ：child cretinism(呆小症) adult myxedema(黏液水肿) Calorigenic Effects : Increase the basal metabolic rate and excessive production of heat Improve the sensitivity of sympathetic—The susceptibility of adrenal system
Thyroid hormone-Pharmacological mechanism o Mediated by activating its nuclear specificity T3 recepTors o T4 translated into T3 by deiodination and combined with the specificity T3 receptors, and regulate gene transcription, protein synthesis and play functions o Other factors lead to the decreasing in T3 receptors
Thyroid hormone—Pharmacological mechanism Mediated by activating its nuclear specificity T3 receptors. T4 translated into T3 by deiodination and combined with the specificity T3 receptors, and regulate gene transcription, protein synthesis and play functions Other factors lead to the decreasing in T3 receptors