Why are more severe injury induced by reestablishment of blood flow after ischemia? MICROVASCULAR DAMAGE-NO-Reflow Phenomenon t Vaso-endotheljial edema ATP depletion -decreased Na+-K+ pump function - Na+ and water +entering cell -endothelial edema Vaso-endothelial damage WBC adherence -OfR increase and no decrease t Microvascular obstruction Squeeze of the coronary arteries induced by ischemic myocardium and by interstitial edema of myocardium Adherence, Aggregation and Activation of WBC
Why are more severe injury induced by reestablishment of blood flow after ischemia? Vaso-endothelial edema ATP depletion decreased Na+-K+ pump function Na+ and water entering cell endorthelial edema Vaso-endothelial damage WBC adherence OFR increase and NO decrease Microvascular obstruction Squeeze of the coronary arteries induced by ischemic myocardium and by interstitial edema of myocardium Adherence, Aggregation and Activation of WBC MICROVASCULAR DAMAGE—NO-Reflow Phenomenon
Pathogenesis of ischemia repertusion injur
Pathogenesis of ischemiareperfusion injury
1. Injury of free radicals
1. Injury of free radicals O2
(1)Free radical Free radical--atoms, molecules or ions with unpaired electrons on an otherwise open shell configuration These unpaired electrons are usually highly reactive, so radicals are likely to take part in chemical reactions 1)Oxygen free radical 2 Lipid radical
(1) Free radical Free radical——atoms, molecules or ions with unpaired electrons on an otherwise open shell configuration. These unpaired electrons are usually highly reactive, so radicals are likely to take part in chemical reactions. 1)Oxygen free radical 2)Lipid radical
(2)Oxygen free radical, OFR Types (1)the superoxide anion(O2) (2 the hydroxyl radical (oH (3 singlet oxygen (102) (4 hydrogen peroxide(H2O2)
(2) Oxygen free radical, OFR Types： (1)the superoxide anion (O2 -) (2)the hydroxyl radical (OH ·) (3)singlet oxygen (1O2 ) (4)hydrogen peroxide (H2O2 )