Clinical differentiation Disorders of vessel:female,purpura of skin Disorders of platelet:famale,purpura or ecchymosis of skin,common positions of bleeding are eyeground,gut,uterus Disorders of coagulation:male,often bleed into joints or gut,bleeding occurs after surgery or trauma
Laboratory findings Primary test Ⅻ PK HMWK ←一PTT 。 Vessel:BT,CRT(capillary resistance test) Platelet:account of →以 platelet,CRT(clot retraction test),BT,CRT(capillary X resistance test) Coagulation:CT,APTT,PT,P Prothrombin Thrombin CT,TT Fibrinogen →Fibrins →Fibrin
Laboratory findings Diagnostic test Steps of diagnose Vessel:mirror of capillary, Is disease of hemorrhage? mensuration of vWF,ET-1,TM Disorder blood vessel? Platelet:account, Platelet?Coagulation? configuration,mean volume, Abnormal quantity or abnormal function,antibody of platelet quality? 。 Coagulation:mensuration of all Congenital or acquired? clot bleeding factors If congenital,test gene. 。 Anticoagulation:AT,anticoagula tion of SLE,PC,PS,TM Fibrinolytic:3P test,FDP,D- DI,PLG,t-PA
Treatment Inject platelets or clotting factor Medicine for hemostasis Medicine for produce more platelets Treatment for gene:hemophilia Anticoagulation or Anticongregation of platelets:DIC,TTP Plasmapheresis:TTP,severe ITP Surgery Chinese medicine
Chapter 2--Allergic Purpura