Introduction ·Properties of LSC: self-renewal,quiescent,proliferation,multi-potentiality?, differentiation damaged Immunophenotype of LSC AML CD34+CD38-CD71-CD90-CD117+CD123+,HLA- DR-; CML CD34+CD38-
Introduction • Properties of LSC: self-renewal,quiescent,proliferation,multi-potentiality? , differentiation damaged . Immunophenotype of LSC : AML CD34+CD38-CD71-CD90-CD117+ CD123+,HLADR-; CML CD34+CD38-
Acute Leukemia
Acute Leukemia
Acute Leukemia ·Definition characterized by a huge(massive) accumulation of blastcells the infiltration of these blastcells result in 1 suppression of normal hematopoiesis lead to anemia,infection,bleeding 2 )clinic manifestation related to involvement of organs outside BM
Acute Leukemia • Definition characterized by a huge(massive) accumulation of blastcells .the infiltration of these blastcells result in ： 1 ）suppression of normal hematopoiesis lead to anemia,infection,bleeding 2 ）clinic manifestation related to involvement of organs outside BM
Acute Leukemia ·Classification: 1976 Morphologic Classifying by International FAB cooperative group 1980 MIC Morphology,Immunology, Cytogenetics 2001 WHO
Acute Leukemia • Classification： 1976 Morphologic Classifying by International FAB cooperative group ， 1980 MIC ，Morphology, Immunology, Cytogenetics 2001 WHO
Acute Leukemia FAB classification ALL: L1: lymphoblast cells are small, usually 12 um in diameter.with scanty cytoplasm and inconspicuous(indistinctive) nucleoli.more common in children (approximately 85%of children cases of AL).Prognosis is batter
Acute Leukemia • FAB classification ALL： L1: lymphoblast cells are small, usually < 12 um in diameter .with scanty cytoplasm and inconspicuous(indistinctive) nucleoli .more common in children (approximately 85% of children cases of AL).Prognosis is batter