Introduction ·Incidence ·The total morbidity: 1.8 2.67/100 thousands 1.6 higher than the 1.4 1.2 chance to win a 1 0.8 lottery(1/400 0.6 0.4 thousands 0.2 AML ALL CLL 。男：女=1.8：1
Introduction • Incidence • The total morbidity : 2.67/100 thousands higher than the chance to win a lottery(1/400 thousands ) • 男：女=1.8：1 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 AML ALL CLL
Introduction ·Prognosis 100% BMT CHEMO 0 1 234 5 YEAR
Introduction • Prognosis 100% 0 1 2 3 4 5 YEAR BMT CHEMO
Introduction Etiology and Pathogenes Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Bemzene poisoning lonizing radiation
• Etiology and Pathogenesis Virus ATLV HTLV-I HTLV-II HTLV-III Chemical substance Bemzene poisoning Ionizing radiation Introduction
Introduction ·Pathogenesis Normal Stem cell mutation Leukemic stem cell Progenitor cells Blast cell
Introduction • Pathogenesis Normal Stem cell Blast cell Leukemic stemcell mutation Progenitor cells
Introduction 1)those that confer a proliferative or and survival KIT FLT:3↑，NF-1↓ ● 2)those that impair hematopoietic differentiation and confer properties of self-renewal RUNX1-ETO,CBFB-SMMHC TEL- RONX1 fusions mutation
Introduction • 1)those that confer a proliferative or and survival KIT FLT3 ↑， NF-1 ↓ • 2) those that impair hematopoietic differentiation and confer properties of self-renewal RUNX1-ETO,CBFB-SMMHC ,TELRONX1 fusions mutation