Pathogenesis Influenza is characterised by fever, myalgia headache and pharyngitis. In addition there may be cough and in severe cases prostration. There is usually not coryza鼻炎 (runny nose)which characterises common cold infections Infection may be very mild, even asymptomatic, moderate or very severe
26 Pathogenesis • Influenza is characterised by fever, myalgia, headache and pharyngitis. In addition there may be cough and in severe cases, prostration. There is usually not coryza鼻炎 (runny nose) which characterises common cold infections. • Infection may be very mild, even asymptomatic, moderate or very severe
Transmission Source of infection: patients and carriers AEROSOL 100.000T01.000.000∨R|ONS PER DROPLET 18-72 HR INCUBATION
27 Transmission • Source of infection: patients and carriers. • AEROSOL – 100,000 TO 1,000,000 VIRIONS PER DROPLET • 18-72 HR INCUBATION
Major contributors to Antibody fUture uture profection pathogenesis of influenza syndrom T-cell responses Immune response y Less frequent outcomes Interferon induction nodulation Replication desquamation mucus-secreti Influenza In respirator tract d ciliated cel syndrome Pneumonia Secondary bacterial infection -1 Primary viral pneumonia involvemenT< CNS, muscle
28 Aerosol Inoculation Of virus
NORMAL TRACHEAL MUCOSA 3 DAYS POST-INFECTION 7 DAYS POST-INFECTIEN
29 NORMAL TRACHEAL MUCOSA 3 DAYS POST-INFECTION 7 DAYS POST-INFECTION
SYMPTOMS FEVER HEADACHE MYALG|A(肌痛) COUGH RH|NTS(鼻炎) OCULAR SYMPTOMS
30 SYMPTOMS • FEVER • HEADACHE • MYALGIA(肌痛) • COUGH • RHINITIS(鼻炎) • OCULAR SYMPTOMS