CDC
Brucella The Brucella ts of s cles four of which cause human brucellosis Af 鲁菌病: Brucella melitensis羊布鲁菌, Brucella suis猪布鲁菌, Brucella abortus 牛布鲁菌, and Brucella canis犬布鲁菌 Are all intracellular organisms .B neotomae.B ovis
Brucella • The genus Brucella consists of six species, four of which cause human brucellosis 布 鲁菌病： Brucella melitensis 羊布鲁菌, Brucella suis 猪布鲁菌, Brucella abortus 牛布鲁菌, and Brucella canis 犬布鲁菌 • Are all intracellular organisms • B. neotomae; B. ovis
Brucella are small(0.40.8 X05-1.5 u m), non-motile. non-capasulate, gram negative coccobacilli The organism is aerobic, and their nutritional requirements are complex. All strains grow best in a medium enrich with animal serum and glucose 5-10% carbon dioxide
• Brucella are small (0.4～0.8 ×0.5～1.5μm), non-motile, non-capasulate, gramnegative coccobacilli. • The organism is aerobic, and their nutritional requirements are complex. • All strains grow best in a medium enrich with animal serum and glucose • 5-10% carbon dioxide
Antigenic Structure and classification Two main antigen: A and m The three main brucella differ from one another in the amount or the two main antigen they have In common B abortus A M=20: 1 B melitenSis.A M=1: 20 B suis: A: M=2: 1
Antigenic Structure and classification • Two main antigen: A and M • The three main Brucella differ from one another in the amount or the two main antigen they have in common : B.abortus : A:M=20:1 B.melitensis: A:M=1:20 B.suis: A:M=2:1
B. abortus Bacteria is excreted in genital secretions (including semen), milk, colostrum Survival time Cheese at 40C: 180 days ! Water at 25C: 50 days Meat and salted meat: 65 days Manure at 120C: 250 days !! Widespread: Cattle, Bison, Elk, Deer,Moose,Horse Sheep, Goat, Swine, Donkey, Dogs, Birds, Hares, Fox, Rats mice. Camels and Human
B. abortus • Bacteria is excreted in genital secretions (including semen), milk, colostrum. • Survival time: Cheese at 4oC: 180 days !!! Water at 25oC: 50 days Meat and salted meat: 65 days Manure at 12oC: 250 days !!!! • Widespread: Cattle, Bison, Elk, Deer, Moose, Horse, Sheep, Goat, Swine, Donkey, Dogs, Birds, Hares, Fox, Rats, mice, Camels and Human