Replication Influenza transcribe and replicates its genome in the target cell nucleus assemble and buds from the plasma membrane
11 Replication • Influenza transcribe and replicates its genome in the target cell nucleus • assemble and buds from the plasma membrane
Influenza virus RELEASE BUDDING ATTACHMENT PACKAGI NG POST-TRANSLATIONAL PROC ESSI NG ENDOCYTOSIS TRANSLATION ACIDIFICATION RNA<+ FUSIONA UNCOATING rRNA<- AEDF状 CRNA<+> Cytoplasm
12 Influenza virus
Antigen Soluble antigens: include ribonucleoprotein and M protein which are much stable in antigenicity Surface antigens: include HA and NA which are much variable in antigenicity
13 Antigen • Soluble antigens: include ribonucleoprotein and M protein which are much stable in antigenicity. • Surface antigens: include HA and NA which are much variable in antigenicity
Types o Influenza viruses are divided into 3 groups determined by the ribonucleoprotein(RNP) antigen and M antigen Group a- This group is the cause of epidemics and pandemics and has an avian intermediate host(Ih Group B- This group causes epidemics and has no Ih Group C- This group does not cause epidemics and causes mild disease
14 Types • Influenza viruses are divided into 3 groups determined by the ribonucleoprotein (RNP) antigen and M antigen: • Group A - This group is the cause of epidemics and pandemics and has an avian intermediate host (IH) Group B - This group causes epidemics and has no IH Group C - This group does not cause epidemics and causes mild disease
TYPE A TYPE B TYPE C severity of illness +++ animal reservoir yes no no human pandemics yes no no human epidemics yes no(sporadic) antigenic changes shift, drift drift drift segmented genome yes yes yes amantadine, rimantadine sensitive no effect no effect zanamIvir sensitive sensitive surface glycoproteins
15 TYPE A ++++ yes yes yes shift, drift yes sensitive sensitive 2 severity of illness animal reservoir human pandemics human epidemics antigenic changes segmented genome amantadine, rimantidine zanamivir surface glycoproteins TYPE B ++ no no yes drift yes no effect sensitive 2 TYPE C + no no no (sporadic) drift yes no effect (1)