2. Cata bolism of fatty acid 口 Process:β- oxidation of saturated fatty acid (Fig) Acivation of fatty acid-fatty acyl-coA >Dehydrogenation(B-oxidation >hydration > Dehydrogenation(B-oxidation) >Thiolysis split
❑Process: -oxidation of saturated fatty acid (Fig.) ➢Acivation of fatty acid– fatty acyl-CoA ➢Dehydrogenation (-oxidation) ➢Hydration ➢Dehydrogenation (-oxidation) ➢Thiolysis \split 2. Catabolism of fatty acid
2. Cata bolism of fatty acid 口 Concept:β- oxidation Oxidation of B-c offatty acid, which undergo 4 reactions: dehydrogenation, hydration dehydrogenationagain) and thiolysis split in turn the fatty acid chain then reduce 2C and produce/ ace tyl CoA
❑Concept: -oxidation Oxidation of -C of fatty acid, which undergo 4 reactions: dehydrogenation, hydration, dehydrogenation (again) and thiolysis \split in turn, the fatty acid chain then reduce 2C and produce 1 acetyl CoA. 2. Catabolism of fatty acid
2. Cata bolism of fatty acid 口 Position: role of carnitine<肉(毒)碱> B-oxidation of fatty acid occurred in mitochondria while the activation of fatty acid is in cytosol Fatty acyl-CoA carnitine> fatty acyl-carnitine CoA ( fatty acyl-CoA: carnitine fatty acyl transferase) Fatty acyl-carnitine can permeate membrane of mitochondria (Fig
2. Catabolism of fatty acid ❑Position : role of carnitine <肉(毒)碱> -oxidation of fatty acid occurred in mitochondria, while the activation of fatty acid is in cytosol. Fatty acyl-CoA + carnitine → fatty acyl-carnitine + CoA (fatty acyl-CoA: carnitine fatty acyl transferase) < Fatty acyl-carnitine can permeate membrane of mitochondria.> (Fig.)
2. Cata bolism of fatty acid 口 Energy Acivation of fatty acid 2 ATP >B-oxidation 1 FADH +1 NADH 5 ATP >Oxidation per acetyl CoA 12 ATP How many acetyl Coa will be produced per fatty acid? >Cn/2 acetyl CoA and (Cn/2)-/FADH NADH (It is suggested that n is even
2. Catabolism of fatty acid ❑Energy: ➢Acivation of fatty acid -2 ATP ➢-oxidation 1 FADH +1 NADH 5 ATP ➢Oxidation per acetyl CoA 12 ATP How many acetyl CoA will be produced per fatty acid? →Cn/2 acetyl CoA and (Cn/2)-1 [FADH + NADH] (It is suggested that n is even.)
2. Cata bolism of fatty acid 口 Energy:(Cont) ATP=17 Cn/2-7(n is even) e.g. Palmitate(c16) yields 129 ATP when oxidized to co, and HO The energy efficiency is 129X7.3/2340=40.24% Q1分子三硬脂酸甘油脂彻底氧化产生多少ATP? uOdd-number fatty acids--1 propionyl COA (羧化)→甲基丙二酸单酰CoA→(变位→琥珀酰CoA <eg深海鱼油>
2. Catabolism of fatty acid ❑Energy: (Cont.) ATP = 17 Cn/2 –7 ( n is even) e.g. Palmitate(C16) yields 129 ATP when oxidized to CO2 and H2O. The energy efficiency is 129 × 7.3 / 2340 = 40.24% Q: 1分子三硬脂酸甘油脂彻底氧化产生多少ATP? ❑Odd-number fatty acids -- 1 propionyl CoA (羧化)→甲基丙二酸单酰CoA→(变位)→琥珀酰CoA <e.g. 深海鱼油>