Permeability of small molecules through lipid membrane hydrophobic fre Ons H,O,urea glt ucose sucrose H, Na, K, HCO3, CL benzene glycerol C O, membrane glycerol HO urea n CL KTNa 10 10-10 Permeability(cm/sec)
Permeability of small molecules through lipid membrane hydrophobic free-charge polar free-charge polar charged ions O2, N2 , H2O,urea, glucose sucrose H+ ,Na+ ,K+ , HCO3 - , CLbenzene glycerol C O2, _____ __________ _ membrane glycerol glucose H2O urea tryptophen CL- K+ Na+ 10-2 10-4 10-6 10-8 10-10 10-12 Permeability (cm/sec)
SMALL HYDROPHOBIC MOLECULES N2 benzene SMALL UNCHARGEDH20 POLAR glycerol ethanol MOLECULES UNCHARGED amino acids LARGER POLAR glucose nucleotides MOLECULES Na HCO K IONS Ca*, CI M synthetic lipid bila
2) Four basic mechanism by which solute molecules move across membrane actIve nonmediated carrier mediated B C d membrane D simple diffusion simple diffusion facilitated diffusion active transport through bilayer through channel
2） Four basic mechanism by which solute molecules move across membrane Passive active nonmediated carrier mediated A B C d membrane a b c D simple diffusion simple diffusion facilitated diffusion active transport through bilayer through channel
被动输运 主动输运 非载体介导 载体介导 A B C eeeee eeeeee C D
transported molecule channe carrier protein protein concentration bilayer gradient simple channel- carrier- diffusion mediated mediated PASSⅣ VE TRANSPORT ACTIVE TRANSPORT