COMPENSATORY MECHANISM Increase Interstitial Fluid Decrease outfl venous end arterial end In shock Fluid shift system
COMPENSATORY MECHANISM Blood Capillary Venous Blood Hydrostatic Pressure = 30 mmHg H venous end Colloid Osmotic Pressure= 25 mmHg Arterial Blood Interstitial Fluid Decrease outflow Increase inflow In shock arterial end Fluid shift system
CELLULAR CHANGES Cell membrane ion pump dysfunction Leakage of intracellular contents into the extracellular space Intracellular pH dysregulation
CELLULAR CHANGES • Cell membrane ion pump dysfunction • Leakage of intracellular contents into the extracellular space • Intracellular pH dysregulation
RESULTANT SYSTEMIC CHANGES Initial signs of end organ dysfunction Tachycardia ° Tachypnea Metabolic acidosis Oliguria Cool and clammy skin
RESULTANT SYSTEMIC CHANGES • Initial signs of end organ dysfunction • Tachycardia • Tachypnea • Metabolic acidosis • Oliguria • Cool and clammy skin