Giving lecture by Multimedia teaching methods Interactive teaching 5.教学评价 课后间题：Textbook,Chapter6,PRACTICE PROBLEMS FOR STUDENT USE 第七章Ionic equilibria 1.教学目标 Describe the Bronsted-Lowry and Lewis electronic theories. Identify and define the four classifications of solvents. Understand the concepts of acid-base equilibria and the ionization of weak acids and weak bases. Understand the concepts of pH,pK,and pOH and the relationship between hydrogen ion concentration and pH. Define strong acid and strong base. Define and calculate acidity constants 2.教学重难点 Broensted-Lowry and Lewis electronic theories; Acid-base equilibria and ionization; pH calculation of various systems. 3.教学内容 Broensted-Lowry theory and Lewis electronic theory Acid-base equilibria lonization of weak acids,ionization of weak bases,ionization of water,ionization of polyprotic electrolytes,ampholytes Species concentration as a function of pH Calculation of pH Proton balance equations,conjugated acid-base pairs,solutions containing only a weak acid,solutions containing only a weak base, solution containing a single conjugate acid-base pair,two conjugate acid-base pair,solutions containing only a diprotic acid, solutions containing only an ampholyte,solutions containing only a diacidic base,two independent acid-base pairs,solutions containing two weak acids,solutions containing a salt of a weak acid and a weak base,solutions containing a weak acid and a weak base
• Giving lecture by Multimedia teaching methods • Interactive teaching 5. 教学评价 课后问题：Textbook, Chapter 6, PRACTICE PROBLEMS FOR STUDENT USE 第七章 Ionic equilibria 1. 教学目标 • Describe the Br¨onsted–Lowry and Lewis electronic theories. • Identify and define the four classifications of solvents. • Understand the concepts of acid–base equilibria and the ionization of weak acids and weak bases. • Understand the concepts of pH, pK, and pOH and the relationship between hydrogen ion concentration and pH. • Define strong acid and strong base. • Define and calculate acidity constants 2. 教学重难点 • Broensted-Lowry and Lewis electronic theories; • Acid-base equilibria and ionization; • pH calculation of various systems. 3. 教学内容 • Broensted-Lowry theory and Lewis electronic theory • Acid-base equilibria Ionization of weak acids, ionization of weak bases, ionization of water, ionization of polyprotic electrolytes, ampholytes • Species concentration as a function of pH • Calculation of pH Proton balance equations, conjugated acid-base pairs, solutions containing only a weak acid, solutions containing only a weak base, solution containing a single conjugate acid-base pair, two conjugate acid-base pair, solutions containing only a diprotic acid, solutions containing only an ampholyte, solutions containing only a diacidic base, two independent acid -base pairs, solutions containing two weak acids, solutions containing a salt of a weak acid and a weak base, solutions containing a weak acid and a weak base
Acidity constants Effect of ionic strength 4.教学方法 Giving lecture by Multimedia teaching methods Interactive teaching 5.教学评价 课后问题：Textbook,Chapter7,PRACTICE PROBLEMS FOR STUDENT USE 第八章Buffered and isotonic solutions 1.教学目标 Understand the common ion effect. Understand the relationship between pH,pKa,and ionization for weak acids and weak bases. Understand the relationship between activity coefficients and the buffer equation Discuss the factors influencing the pH of buffer solutions. Understand the concept and be able to calculate buffer capacity. Describe the influence of concentration on buffer capacity. Discuss the relationship between buffer capacity and pH on tissue irritation. Describe the relationship between pH and solubility. Describe the concept of tonicity and its importance in pharmaceutical systems. 2.教学重难点 Broensted-Lowry and Lewis electronic theories; Acid-base equilibria and ionization. 3.教学内容 The buffer equation Common ion effect,buffer equation for a weak acid and its salt,activity coefficients and the buffer equation,some factors influencing the pH of buffer solutions,drugs as buffers,pH indicators Buffer capacity
• Acidity constants Effect of ionic strength 4. 教学方法 • Giving lecture by Multimedia teaching methods • Interactive teaching 5. 教学评价 课后问题：Textbook, Chapter 7, PRACTICE PROBLEMS FOR STUDENT USE 第八章 Buffered and isotonic solutions 1. 教学目标 • Understand the common ion effect. • Understand the relationship between pH, pKa, and ionization for weak acids and weak bases. • Understand the relationship between activity coefficients and the buffer equation. • Discuss the factors influencing the pH of buffer solutions. • Understand the concept and be able to calculate buffer capacity. • Describe the influence of concentration on buffer capacity. • Discuss the relationship between buffer capacity and pH on tissue irritation. • Describe the relationship between pH and solubility. • Describe the concept of tonicity and its importance in pharmaceutical systems. 2. 教学重难点 • Broensted-Lowry and Lewis electronic theories; • Acid-base equilibria and ionization. 3. 教学内容 • The buffer equation Common ion effect, buffer equation for a weak acid and its salt, activity coefficients and the buffer equation, some factors influencing the pH of buffer solutions, drugs as buffers, pH indicators • Buffer capacity
Approximate calculation of buffer capacity,maximum buffer capacity,the influence of concentration on buffer capacity Buffers in pharmaceutical and biological systems In vivo biologic buffer systems,urine,pharmaceutical buffers,procedures for preparing pharmaceutical buffer solutions,pH on tissue irritation,stability versus optimum therapeutic response,pH and solubility Buffered isotonic solutions Measurement of tonicity,calculating tonicity using Liso values Methods of adjusting tonicity and pH Cryoscopic method,sodium chloride equivalent method,White-Vincent method,the Sprowls method 4. 教学方法 Giving lecture by Multimedia teaching methods Interactive teaching 5.教学评价 课后问题：Textbook,Chapter&,PRACTICE PROBLEMS FOR STUDENT USE 第九章Solubility and distribution 1.教学目标 Define saturated solution,solubility,and unsaturated solution. Define complete and partial miscibility. Define thermodynamic,kinetic,and intrinsic solubility. Describe and give examples of polar,nonpolar,and semi polar solvents. Understand the factors controlling the solubility of weak electrolytes. Describe the influence of solvents and surfactants on solubility. Measure thermodynamic solubility. Describe what a distribution coefficient and partition coefficient are and their importance in pharmaceutical systems. 2.教学重难点 教学重点 Thermodynamic,kinetic,and intrinsic solubility
Approximate calculation of buffer capacity, maximum buffer capacity, the influence of concentration on buffer capacity • Buffers in pharmaceutical and biological systems In vivo biologic buffer systems, urine, pharmaceutical buffers, procedures for preparing pharmaceutical buffer solutions, pH on tissue irritation, stability versus optimum therapeutic response, pH and solubility • Buffered isotonic solutions Measurement of tonicity, calculating tonicity using Liso values • Methods of adjusting tonicity and pH Cryoscopic method, sodium chloride equivalent method, White-Vincent method, the Sprowls method 4. 教学方法 • Giving lecture by Multimedia teaching methods • Interactive teaching 5. 教学评价 课后问题：Textbook, Chapter 8, PRACTICE PROBLEMS FOR STUDENT USE 第九章 Solubility and distribution 1. 教学目标 • Define saturated solution, solubility, and unsaturated solution. • Define complete and partial miscibility. • Define thermodynamic, kinetic, and intrinsic solubility. • Describe and give examples of polar, nonpolar, and semi polar solvents. • Understand the factors controlling the solubility of weak electrolytes. • Describe the influence of solvents and surfactants on solubility. • Measure thermodynamic solubility. • Describe what a distribution coefficient and partition coefficient are and their importance in pharmaceutical systems. 2. 教学重难点 教学重点 • Thermodynamic, kinetic, and intrinsic solubility
The factors controlling the solubility of weak electrolytes. The influence of solvents and surfactants on solubility. 教学难点 Polar,nonpolar,and semi-polar solvents 。 Distribution coefficient and partition coefficient and their importance in pharmaceutical systems. 3.教学内容 Thermodynamic,kinetic,and intrinsic solubility.The factors controlling the solubility of weak electrolytes.The influence of solvents and surfactants on solubility.Polar,nonpolar,and semi-polar solvents.Distribution coefficient and partition coefficient and their importance in pharmaceutical systems. 4.教学方法 Giving lecture by Multimedia teaching methods Interactive teaching 5.教学评价 课后问题：Textbook,Practice problems for student 第十章Complexation and protein binding 1.教学目标 Define the three classes of complexes. Describe chelates,their physical properties,and what differentiates them from organic molecular complexes. Describe the types of forces that hold together organic molecular complexes and give examples. Describe the forces involved in polymer-drug complexes used for drug delivery and situations where reversible or irreversible complexes may be advantageous. Identify pharmaceutically examples of the three classes of complexes. Discuss the uses and give examples of cyclodextrins in pharmaceutical applications. Determine the stoichiometric ratio and stability constant for complex formation. Describe the methods of analysis of complexes and their strengths and weaknesses
• The factors controlling the solubility of weak electrolytes. • The influence of solvents and surfactants on solubility. 教学难点 • Polar, nonpolar, and semi-polar solvents. • Distribution coefficient and partition coefficient and their importance in pharmaceutical systems. 3. 教学内容 Thermodynamic, kinetic, and intrinsic solubility. The factors controlling the solubility of weak electrolytes. The influence of solvents and surfactants on solubility. Polar, nonpolar, and semi-polar solvents. Distribution coefficient and partition coefficient and their importance in pharmaceutical systems. 4. 教学方法 • Giving lecture by Multimedia teaching methods • Interactive teaching 5. 教学评价 课后问题：Textbook, Practice problems for student 第十章 Complexation and protein binding 1. 教学目标 • Define the three classes of complexes. • Describe chelates, their physical properties, and what differentiates them from organic molecular complexes. • Describe the types of forces that hold together organic molecular complexes and give examples. • Describe the forces involved in polymer-drug complexes used for drug delivery and situations where reversible or irreversible complexes may be advantageous. • Identify pharmaceutically examples of the three classes of complexes. • Discuss the uses and give examples of cyclodextrins in pharmaceutical applications. • Determine the stoichiometric ratio and stability constant for complex formation. • Describe the methods of analysis of complexes and their strengths and weaknesses