03-Monoclonal antibody therapy Monoclonal antibody therapy clonal antibodies (mAb) tively apyandioactiedbselocal 之c es on a Contents :2 body structure and function … 4.3A rug conjuga ne therapy Antibody structure and function mately 150 kDa and are co ed of two kinds of Da)and the lig o(n da ()By for the Some some m s include ErbB2. and are m%of bres cancer tmor celSuch breow HERposiive specific antigens presented on the surfaces of tumors. History on n und mAb lly short-liv rith blood
03-Monoclonal antibody therapy
Murine gufx b).These na technolo for which an MA点. Fv,single-chain Fv fragm gy.tran Chimeric and humanized To reduce murine antibody imm enicity (attacks by the in ainst the antibody),murine molecules were en ered to ent a une syTh was in ly a d by the prod at murin Human monoclonal antibodies Targeted conditions Cancer Autoimmune diseases Monoclonal antibodie mab.which are effective io rhe is by their abil ofadou (E)and is moderate-severe Alzheimer's disease Therapy types Radioimmunotherapy
Radioim Antibody-directed enzyme prodrug therapy Antibody-drug conjugate Immunoliposome therapy Checkpoint therapy the TME sed by B cells FDA approved therapeutic antibodies
Brand name Company e n 1222194 chimerc Fab 1a357 Abbvie 12312002 fully haman TNE 125057 A.mgen 9232016 TNF 61024 2222m1n HER2 25 57/21 CD52 242015 ully huma 2555 5/182016 o 6103 101B2016 6104 EMD Sereo 3232017 PD-LI 7610 5/12/1930 chimeric 1037 39201 fully haman Avastin 2262004 humanized VEGF 12500 Merck 10212016 1232014 125557 gea 12530 215201 761032 6/172009 125319 10281996 6 UCB(con 4222008 TNF Croho's disease 12516间 2/120m EGER Roche 12101997 且2RA 11/162015 fully heman
Prolia,Xgeva Amge 612010 ully huma RANKI 125120 /10201 GD 12551 3282017 fully human 761055 5/12017 fully heman PD-LI 61069 3y162007 2516 113020151 humanized 76103 8272015 fully haman PCSK9 1255 4242009 fully hama 2528 7/12013 TNF 125433 219202 2501 6 10y162015 6102 421201 TNE 452D16 chimeric,biosimilar TNF Bris-Myers 32520 CTLA-4 Eli Lilly 3222016 IL17A 1142015 ILS 232D04 1242015 EGER 122220144 PD- 12555 6 pdivo 342D15 PD-1 182016 halational anthra 12550 12540