Cutaneous anthraxAB
Cutaneous anthrax
Pulmonary AnthraxSpore inhalation and phagocytosisGermination, replicate and infection ofhilar l ymph nodesHemorrhagic necrosis of lymph nodesFever, malaise, myalgia, and nonproductive coughSystemic spread and in death within 24hoursSHIHEZI UNIVERSITY
Pulmonary Anthrax Spore inhalation and phagocytosis Germination, replicate and infection of hilar lymph nodes Hemorrhagic necrosis of lymph nodes Fever, malaise, myalgia, and nonproductive cough Systemic spread and in death within 24 hours SHIHEZI UNIVERSITY
Gastrointestinal AnthraxIngestion of infected meat Proliferation within the GI tracEpithelial invasion and ulcerationSpreads to mesenteric lymph nodes Septicemia and shockSHIHEZI UNIVERSITY
Gastrointestinal Anthrax Ingestion of infected meat Proliferation within the GI tract Epithelial invasion and ulceration Spreads to mesenteric lymph nodes Septicemia and shock SHIHEZI UNIVERSITY
Virulence FactorsCapsule (plasmid codedEFILF++: virulent strainbunecnamembrana-: non-virulent strainExotoxins (plasmid codedKkorple poteni poendocytoze wntirbunky edema factor (EF) lethal factor (LF)sruktumizmenaykyselem prostiedendzomi zpisobiaprotective antigen (PA)urdineri prteni EfaLFSHIHEZI UNIVERSITY
Virulence Factors Capsule (plasmid coded) +: virulent strain -: non-virulent strain Exotoxins (plasmid coded) edema factor (EF) lethal factor (LF) protective antigen (PA) SHIHEZI UNIVERSITY
B. anthracis capsule Polypeptide of D-glutamic acid Plasmid encoded AntiphagocyticNot a good immunogenAntibodies to the capsule are not protectiveagainst the diseaseSHIHEZI UNIVERSITY
B. anthracis capsule Polypeptide of D-glutamic acid Plasmid encoded Antiphagocytic Not a good immunogen Antibodies to the capsule are not protective against the disease SHIHEZI UNIVERSITY