Pathogenesis Key point ☆ Type I pneumocytes Very susceptible to injury Cannot regenerate .g Type ll pneumocytes More resistant to injury Regenerate and differentiate into Type i pneumocytes Proliferate in injury laying down a new epithelial layer
Pathogenesis – Key point Type I pneumocytes Very susceptible to injury Cannot regenerate Type II pneumocytes More resistant to injury Regenerate and differentiate into Type I pneumocytes Proliferate in injury laying down a new epithelial layer
Pathogenesis o Fibroblasts migrate across the damaged alveolar wall into the alveolar space and into the fibrin-rich exudate fibrin is organized, collagenized and covered by alveolar epithelium
Fibroblasts migrate across the damaged alveolar wall into the alveolar space and into the fibrin-rich exudate Fibrin is organized, collagenized and covered by alveolar epithelium Pathogenesis
If the injury persists Fibrosis continues, leading to obliteration of the delicate interstitium Normal lung architecture is distorted because fibrosis scars down“ pulling” on bronchiolar spaces causing dilatation and a cyst-like architecture Final stage is referred to as End stage lung or Honey Comb lung
If the injury persists… Fibrosis continues, leading to obliteration of the delicate interstitium Normal lung architecture is distorted because fibrosis scars down ―pulling‖ on bronchiolar spaces causing dilatation and a cyst-like architecture Final stage is referred to as End Stage Lung or Honey Comb Lung
How to make a diagnosis?
How to make a diagnosis?
Diagnostic path Not idiopathic Possible lIP HRCT Confident UIP Not typieal UTP Diagmostic other ID ?Other ILD Histiocytosis x ete Surgical biopsy BAL/TBB UIP NSIP RB DIP OP LIE Other
Diagnostic path