Structural Ryirior Ioreeimgnt (Folkow's Principle) Hypertensive Normotensive 四> Contraction(%)
Immporsante or Sympathetic Innervation ior yas- cur Strutture in Expsrinmgnsal Hypertension Cerebral arteries 015 p<005p<005 0.1 30.05 WKY SHR- SHR- innervated denervated Hart ct at 1980
Yasgur Siruyurl Comssuenyey oi flyperission Normal blood Hypertension pressure Vascular Intima hypertrophy or hyperplasia Meda→ 'Eutrophic' umen vascular remodeling Wall/lumen: normal increased
T'otal Peripheral Resistancy Ilex af Resi and During Bicycle Exerting in Diiereni Age groups 5000 17-29 years 30-39 years 40-55 years 3000 2000 1000 1100 90百 600 050010001500050010001500050010001500 vo, mllmin/m? Vo. mlmin/m? vo, mumin/m? Normotensive Hypertensives Lund hansen Omvik, 1995
forearm D里 esismngg Response Curye to InimmrigrHiI Norepinephrine 25 5 Hypertensives 20 15 Controls UM丝 10 5 00.2040.6081 SMertsson, 1970 Norepinephrine( log dose-log threshold dose