甲状腺功能减退 Hypothyroidism 复旦大学医学院内分泌科 李益明
甲状腺功能减退 Hypothyroidism 复旦大学医学院内分泌科 李 益 明
Hypothalamic-pituitary thyroid axis Hypothalamus TRH Stimulation Inhibitio Free Hormone Bound Hormone Pituitary Thyroid T3,T4 Binding Proteins TSH Stimulation Thyroid
Hypothalamic-pituitarythyroid axis
HYPOTHALAMUS TRH Somatostatin HYPOFYZA TSH T 3 STITNA ZLAZA Na sech urownich navic dochazi ke konverzi T, na aktivnejsi T3, coz muze hrat roli ve zpetnovazebne kontrole
Overview Clinical syndrome Slowing down of metabolism Slowing of growth and mental retardation in infants and children Generalized slowing down of organism Deposition of glycosaminoglycans in skin and muscle Reversible with therapy
Overview Clinical syndrome Slowing down of metabolism Slowing of growth and mental retardation in infants and children Generalized slowing down of organism Deposition of glycosaminoglycans in skin and muscle Reversible with therapy
Etiology and Classifcation Primary(thyroid failure) t Hashimoto's thyroiditis t lodide deficiency or excessive radioactive iodine therapy for gD ◆ Subtotal thyroidectomy t Subacute thyroiditis Secondary: pituitary deficit Tertiary: hypothalamic dysfunction Peripheral resistance to thyroid hormone
Etiology and Classifcation Primary(thyroid failure) Hashimoto’s thyroiditis Iodide deficiency or excessive Radioactive iodine therapy for GD Subtotal thyroidectomy Subacute thyroiditis Secondary: pituitary deficit Tertiary: hypothalamic dysfunction Peripheral resistance to thyroid hormone