Etiology and Epidemiology 病因与流行病学 ◆1950 肺不张 ◆1955 发现肺表面活性物质。 ◆1959 发现HMD病人肺表面活性物质缺 乏。 米1965 肺表面活性物质主要成分-磷脂酰 胆碱
Etiology and Epidemiology 病因与流行病学 1950 肺不张 1955 发现肺表面活性物质。 1959 发现HMD病人肺表面活性物质缺 乏。 1965 肺表面活性物质主要成分 -磷脂酰 胆碱
Surfactant composition表面活性物质 Protein (SP-A,B,C,D) 11.1% Total lipid 88.1% Phosphatidylcholine胆碱 77.81% (62.9%of this is DPPC) Phosphatidylethanolamine乙醇胺 5.2% Cholesterol胆固醇 8.4% Sphingomyline鞘磷脂 1.5% Lysophosphatidylcholine溶酶体胆碱 0.9%
Surfactant composition表面活性物质 Protein (SP-A,B,C,D) 11.1% Total lipid 88.1% Phosphatidylcholine 胆碱 77.81% (62.9% of this is DPPC ) Phosphatidylethanolamine 乙醇胺 5.2% Cholesterol胆固醇 8.4% Sphingomyline 鞘磷脂 1.5% Lysophosphatidylcholine 溶酶体胆碱 0.9%
Surfactant production表面活性物质产生 Alveolar Type IICells 30 (3001/595)4453993300 Surfactant and maturity 10 24 22 30 33 3639 Gestationsal age(weeks)
Surfactant production表面活性物质产生 Surfactant and maturity 0 1 0 2 0 3 0 2 4 2 7 3 0 3 3 3 6 3 9 Gestationsal a ge(weeks) Surfactant(mcg/100g) Alveolar Type ⅡCells
Epidemiology流行病 HMD INVERSED TO GA >37weeks 32-36weeks <28weeks 0% 20% 40%60% INCIDENCE
Epidemiology流行病 0% 20% 40% 60% INCIDENCE 1 HMD INVERSED TO GA >37weeks 32-36weeks <28weeks
病因 ◆早产：胎龄愈小，发病率越高 ◆胎龄37周<5% ◆32-34周 15%-30% ◆<28周 60%-80%
病 因 早产:胎龄愈小,发病率越高 胎龄37周 <5% 32-34周 15%-30% <28周 60%-80%