Common features of acute leukemias Laboratory findings Anemia 2. Platelet count is usually depressed 3. WBC count is variably elevated Much more important in the circulating blood and the bone marrow
◼ Laboratory findings 1. Anemia 2. Platelet count is usually depressed 3. WBC count is variably elevated Much more important: blasts in the circulating blood and the bone marrow Common features of acute leukemias
Common features of acute leukemias ■ Clinical treatment Chemotherapy Bone marrow stem cell(MSCs)transplantation
◼ Clinical treatment Chemotherapy Bone marrow stem cell(MSCs) transplantation Common features of acute leukemias
Different features between AML andAlL AML ALL Ag Pre-B(85%): children, 4 years adults, median age: 50 yrs Pre-T(15%): adolescent males, 1 5-20vears Fine chromatin: 3-5 Morphology nucleoli, more cytoplasm coarse and clumped chromatin containing granules, 1-2 nucleoli A uer rods histochemistry Peroxidase PAS+ 0 A
Different features between AML and ALL Morphology coarse and clumped chromatin 1-2 nucleoli AML ALL Age adults; median age : 50 yrs Peroxidase + Fine chromatin; 3-5 nucleoli, more cytoplasm containing granules, Auer rods Pre-B(85% ): children, 4 years; Pre-T(15%): adolescent males, 15-20years PAS+ histochemistry
AML ALL Clinical As described previously features 量后 immunoph CDI3 CD14 TdT(95%+) genotyping CD15 CD64 B: CD19 T: CD2 Karyotypic M2: t(8: 21) changes M31517)维甲酸治疗Pre-B: Hyperdiploidy M4:inv(16)/del(16) t(12;21);Ph prognosis Devastating disease Good: 2-10 yrs, pre-B
Clinical features As described previously immunoph enotyping CD13,CD14, CD15, CD64 TdT (95% +) B: CD19 T: CD2 AML ALL Karyotypic changes Pre-B: Hyperdiploidy t (12;21) ; Ph prognosis Good:2-10 yrs, pre-B Devastating disease M2: t(8;21) M3:t(15;17) 维甲酸治疗 M4: inv(16) /del(16)
Chronic myelogenous leukemia. CML ge 15-60 years Peak incidence: 40-50 years Clinical features 1. Onset is slow 2. nonspecific initial symptoms Easy fatigability, weakness, and weight loss 3. Extreme splenomegaly-+ infarct- pai
Age 25-60 years Peak incidence : 40-50 years Clinical features 1. Onset is slow; 2. nonspecific initial symptoms Easy fatigability, weakness, and weight loss 3. Extreme splenomegaly infarct pains Chronic myelogenous leukemia, CML