Lymphoid neoplasms A group of entities that vary widely in terms of their clinical presentation and behavior e Classification scheme that relies on a combination of clinical morphologic, phenotypic and genotypic features the relationship between lymphoma and lymphocytic leukemia Certain important relevant principles most: B Cell origin neoplasms are often composed of cells that arrest at specific stages
Lymphoid neoplasms A group of entities that vary widely in terms of their clinical presentation and behavior Classification scheme that relies on a combination of clinical, morphologic, phenotypic and genotypic features the relationship between lymphoma and lymphocytic leukemia Certain important relevant principles most: B Cell origin neoplasms are often composed of cells that arrest at specific stages
Lymphoid neoplasms I A. Precursor B-cell neoplasms I B. Peripheral B-cell neoplasms NHL IA Precursor T-cell neoplasms IIB. Peripheral T-/NK-cell neoplasms ll. Hodgkin lymphoma
ⅠA. Precursor B-cell neoplasms ⅠB. Peripheral B-cell neoplasms ⅡA. Precursor T-cell neoplasms ⅡB. Peripheral T-/NK-cell neoplasms Ⅲ. Hodgkin lymphoma Lymphoid neoplasms NHL
I A. Precursor B-cell neoplasms 1. Precursor B-cell leukemia/lymphoma IA. Precursor T-cell neoplasms Precursor T-cell leukemia/lymphoma pre-B-lymphoblastic tumor: first leukemia lymphoma pre-T-lymphoblastic tumor: mediastinal masses involved the thymus leukemia Both tumors usually have the clinical appearance of an acute lymphoblastic leukemia (ALL)
ⅠA. Precursor B-cell neoplasms 1. Precursor B-cell leukemia/lymphoma ⅡA. Precursor T-cell neoplasms 1. Precursor T-cell leukemia/lymphoma pre-B-lymphoblastic tumor: first leukemia lymphoma pre-T-lymphoblastic tumor: mediastinal masses involved the thymus leukemia Both tumors usually have the clinical appearance of an acute lymphoblastic leukemia (ALL)
Common features of acute leukemias ALL +AML ■ Clinical features 1. Abrupt stormy onset--within 3 months 2. Symptoms related to depression of normal marrow function Pathophysiology Block in differentiation blasts accumulate in marrow normal hematopoietic stem cells Anemia Mature leukocytes Thrombocytopenia fatigue infection bleeding
Common features of acute leukemias ALL +AML ◼ Clinical features 1. Abrupt stormy onset—within 3 months 2. Symptoms related to depression of normal marrow function Pathophysiology Block in differentiation blasts accumulate in marrow normal hematopoietic stem cells Anemia fatigue Mature leukocytes infection Thromobocytopenia bleeding
Common features of acute leukemias ■ Clinical features 3. Bone pain and tenderness 4. Generalized lymphadenopathy splenomegaly, and hepatomegaly More common in alL 5. Central nervous system manifestations Headache, vomiting, and nerve palsies children adults ALL>AML
◼ Clinical features 3. Bone pain and tenderness 4. Generalized lymphadenopathy splenomegaly, and hepatomegaly More common in ALL 5.Central nervous system manifestations Headache, vomiting, and nerve palsies children ＞adults, ALL＞AML Common features of acute leukemias