Pathogenesis factors o Microbial factors: virulence factors: chlamydia mycoplasma, influenza virus, S. Pneuomiae Mycobacteria, Pneumococccal, polypeptide pneumolysin o Host factors: hypogammaglobulimia, CD4+ T cell reduction, underlying lung disease medicine o Routes of pathogenesis: gross aspiration microaspiration, aerosolization, hematogel d spread, direct spread
Microbial factors: virulence factors: chlamydia, maycoplasma, influenza virus, S. Pneuomiae, Mycobacteria, Pneumococccal, polypeptide pneumolysin. Host factors: hypogammaglobulimia, CD4+ T cell reduction, underlying lung disease, medicine Routes of pathogenesis: gross aspiration, microaspiration, aerosolization, hematogenous spread, direct spread
P aeruginosa virulence factors Pili Biofilm Exos, ExoU, ExoT, ExoY FI Type III secretion agendum Quorum Sensing Type I& ll secretion Non-pilus adhesins P1 lasa elastase (type I Cell-associated factor Lasb elastase(type In) Alkaline protease(type I) Intracellular factors Hemolysins: Phospholipase C(type II) Rhamnolipid Extracellular factors E in A (Type ID) Exoenzyme s P yocyanin, Pyoverdin
Pili Flagellum Non-pilus adhesins Alginate/biofilm LPS Cell-associated factors Quorum Sensing ExoS, ExoU , ExoT, ExoY Type III secretion Intracellular factors Proteases: LasA elastase (type II) LasB elastase (type II) Alkaline protease (type I) Hemolysins: Phospholipase C (type II) Rhamnolipid Exotoxin A (Type II) Exoenzyme S Pyocyanin, Pyoverdin Type I & II secretion Extracellular factors Type III secretion Biofilm
Pathology o Lobar pneumonia: congestion-red hepatization- grey hepatization-resolution o Bronchopneumonia: patchy consolidation neutrophilic exudate centered in bronchi(ioles centrifugal spread o Miliary pneumonia: bloodstream spread or blood dissemination induced numerous discrete lesions(2-3mm in diameter) o Interstitial pneumonia: patchy or diffuse
Lobar pneumonia: congestion-red hepatizationgrey hepatization-resolution Bronchopneumonia: patchy consolidation, neutrophilic exudate centerted in bronchi(ioles), centrifugal spread Miliary pneumonia: bloodstream spread or blood dissemination induced numerous discrete lesions (2-3mm in diameter) Interstitial pneumonia: patchy or diffuse
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Pathology-microscopic