Three steps 1. Recognition(C1 activation The components involved Clg, clr, cls Ag+Ab→IC→ bind o1q→C1r→C1s→C1 2. Activation The components involved C4, C2 and c3 (1C4 and C2 activation, generation of C3 convertase (2 generation of C5 convertase 3. Attack(terminal pathway) The components involved C5, C6, C7, C8, C9 the membrane attack complex MAC C5b6789
Three steps 1. Recognition ( C1 activation ) The components involved：C1q, C1r, C1s Ag + Ab→IC→bind C1q→C1r→C1s →C1 2. Activation The components involved: C4, C2 and C3 (1) C4 and C2 activation, generation of C3 convertase (2) generation of C5 convertase 3. Attack (terminal pathway) The components involved: C5, C6, C7, C8, C9 the membrane attack complex (MAC): C5b6789
Complement Classical pathway C1q C1复合物(C1qr2s2) Clr C1s2 O-06G0-BO 个 鲁桑 Ca C1 molecule
Classical pathway Complement C1 molecule Ca++
STUDENT CONSULT C1q binds to antigen C1 INH complexed antibodies, prevents C1r2S2 resulting in activation from becoming of C1r2S2 proteolytically active B C1q C1 INH Antibody C1r2S2 Clr2s? @ElsevierAbbas&lIchtman:BasicImmunologyUpdated2e-www.studentconsult.coml ownloaded from Student Consut (on 1 June 2006 04: 16 PM) 82005 E/sevier
Downloaded from: StudentConsult (on 1 June 2006 04:16 PM) © 2005 Elsevier
Complement Classical pathway Ca++ C4 C2 C3 Cir XCis C3a C1q C2a / C4a C4b c4b C3b g C2b
Classical pathway Complement Ca++
Complement Ag-Ab complex C1qrs Cars C3 C3 convertase C2 C4一C4b-C4b2 C4b2b C4a C2a C3b C3a C4b2b3b C5 convertase Classical pathway
Complement Classical pathway Ag-Ab complex C3 convertase C5 convertase