Oxygen paradox Hypoxia liquid perfuse organ or culture without oxygen InJury estore perfusion severe Inlury
Oxygen paradox Hypoxia liquid perfuse organ or culture without oxygen injury restore perfusion severe injury
I Cause of ischemia-reperfusion injur y and affecting factor coronary in spasm + antispasmotic thrombosis thrombolytic therapy 1. cause coronary by-pass operation on heart: no-reflow organ transplant
Ⅰ. Cause of ischemia-reperfusion injur y and affecting factor coronary in spasm antispasmotic thrombosis thrombolytic therapy 1. cause coronary by-pass operation on heart: no-reflow organ transplant
2. Affecting factor small 5-10min: arrhythmia (1)ischemic (animals 20-30min: ventricular tremor time big 20-40min: reversible injury animals [40-60min: irreversible injury diversity between small and big animal
2．Affecting factor small 5-10min: arrhythmia ⑴ ischemic animals 20-30min: ventricular time tremor big 20-40min: reversible injury animals 40-60min: irreversible injury diversity between small and big animal
10% 圆图 对照 缺血 缺血加再灌 墨 ATP K Ca Changes of ischemic perfuse:ATP、Ca2+、K+
Changes of ischemic perfuse: ATP、Ca2 + 、K+
(2) collateral( u#)circulation: chronic (302 consumption rate K+1Mg21會 protection (4 electrolytes 1Nat]食Ca2食= damage (5)condition of f, pressure, pH, Na*, Ca2tprotection reperfusion (T, pressure, Na*, C a2+=, damage
⑵ collateral(侧枝) circulation：chronic ⑶ O2 consumption rate [K+ ] , [Mg2+ ] protection ⑷ electrolytes [Na+ ] , [Ca2+ ] damage (5) condition of T, pressure,pH,Na+ ,Ca2+ protection reperfusion T, pressure,Na+ ,Ca2+ damage