Acid-base balance and acid-base disturbance
Acid-base balance and acid-base disturbance
I. regulation of acid-base balance 1. origin of acid and base in the body volatile acid: H2CO3 (15mol/day) sulfuric acid 1) acids phosphoric acid fixed acid: uric acid (90mmol/L) mesostate 2)base: salt of organic acid; NH3
I. regulation of acid-base balance 1. origin of acid and base in the body volatile acid: H2CO3 (15mol/day) sulfuric acid 1) acids phosphoric acid fixed acid: uric acid (90mmol/L) mesostate 2) base: salt of organic acid; NH3
2. regulation of acid-base balance 1)role of buffer HCO-r/cor 53%o Hb/HHb buffer system Hbo.2/HHbO2J 35% Pr/hPr 7 Phosphate 5 Henderson-hasselbalch ph= pKa+ lg Hco 3/H2CO31 =61+g20/1=61+13=74 buffer of fixed acid: hco3HCO buffer of volatile acid: hb/HHb
2. regulation of acid-base balance 1) role of buffer HCO- 3 /H2CO3 53% Hb- /HHb buffer system HbO- 2 /HHbO2 35% Pr- /HPr 7% Phosphate 5% Henderson-Hasselbalch pH = pKa + lg [HCO- 3]/[H2CO3] = 6.1 + lg 20/1 = 6.1 + 1.3 =7.4 buffer of fixed acid: HCO- 3/H2CO3 buffer of volatile acid: Hb- /HHb
血红蛋白缓冲对的缓冲作用 CO,+H,O CA H2CO3 HCO3 H+--Hb CI RBC
血红蛋白缓冲对的缓冲作用 CO2 ClCO2+H2O C.A. H2CO3 HCO- 3 H+ --HbRBC
2)respiratory regulation alteration of ventilation alteration of breathe out of co2 Paco2 t, central [HIt peripheral respiration t PaO2↓J( receptor) Paco2 tt (80mmHg) inhibition of respiratory center 3)cellular action exchanges of Ht and K
2) respiratory regulation alteration of ventilation alteration of breathe out of CO2 PaCO2 central [H+ ] peripheral respiration PaO2 (receptor) PaCO2 (＞80mmHg) inhibition of respiratory center 3) cellular action exchanges of H+ and K+