3) The disadvantage of a disagreeable taste of certain drugs in solution form is overcome when the drug is administered as undissolved particles of an oral suspension (当药物在口服混悬剂中以不溶粒子的形式 给药时可克服某些药物以溶液剂给药时具 有不良气味的缺点)
3）The disadvantage of a disagreeable taste of certain drugs in solution form is overcome when the drug is administered as undissolved particles of an oral suspension. （当药物在口服混悬剂中以不溶粒子的形式 给药时可克服某些药物以溶液剂给药时具 有不良气味的缺点）
Features Desired in a Pharmaceutical Suspension There are many considerations in the development and preparation of a pharmaceutically elegant suspension. 1. A properly prepared pharmaceutical suspension should settle slowly and should be readily redispersed upon gentle shaking of the container (正确制眢的药物混悬剂应沉降缓慢,且 轻微振摇容器后能重新分散)
Features Desired in a Pharmaceutical Suspension There are many considerations in the development and preparation of a pharmaceutically elegant suspension. 1. A properly prepared pharmaceutical suspension should settle slowly and should be readily redispersed upon gentle shaking of the container. （正确制备的药物混悬剂应沉降缓慢，且 轻微振摇容器后能重新分散）
The particle size of the suspensoid should remain fairly constant throughout long periods of undisturbed standing.(混悬剂 应具有长时间放置后其混悬粒子大小保持 不变的特性) 3. The suspension should pour readily and evenly from its container.(混悬剂应易于 从容器中均匀倒出)
2. The particle size of the suspensoid should remain fairly constant throughout long periods of undisturbed standing. （混悬剂 应具有长时间放置后其混悬粒子大小保持 不变的特性） 3. The suspension should pour readily and evenly from its container. （混悬剂应易于 从容器中均匀倒出）
Sedimentation rate of the particles of a Suspension Stokes' Equation dx/dt=d(p; P)g/In where dx/dt is the rate of setting d is the diameter of the particles, Pi is the density of the particle, Pe is the density of the medium. g is the gravitational constant, m is the viscosity of the medium
Sedimentation Rate of the Particles of a Suspension Stokes’ Equation dx/dt=d2 (i -e )g/18 where - dx/dt is the rate of setting - d is the diameter of the particles, - i is the density of the particle, - e is the density of the medium, - g is the gravitational constant, - is the viscosity of the medium
A number of factors can be adjusted to enhance the physical stability of a suspension, including a the diameter of the particles, the density viscosity of the medium 为了减少微粒的沉降速度,可采用的措施有 ①减小微粒的半径, ②加入助悬剂
A number of factors can be adjusted to enhance the physical stability of a suspension, including ◼ the diameter of the particles, ◼ the density, ◼ viscosity of the medium. 为了减少微粒的沉降速度，可采用的措施有： ①减小微粒的半径， ②加入助悬剂