DNA X Figure. Genome of Hepatitis B virus
Figure . Genome of Hepatitis B Virus
Etiology Hepatitis b virus (hbv 1010 antigenic subtypes(mainly adw, adr, ayw, ayr) 10 4 antigen-antibody system HBSAg-anti-HBS HBeAg-anti-HBe HBCAg- anti-HBc(g m Ig g) HBxAg-anti-HBx 10 Partially double-stranded DNA (HBV DNA) 10 very strong resistance Inactivation needs100°℃10′or65℃10h
Hepatitis B virus (HBV) 10 antigenic subtypes(mainly adw, adr, ayw, ayr) 4 antigen – antibody system HBsAg – anti-HBs HBeAg – anti-HBe HBcAg – anti-HBc(Ig M & Ig G) HBxAg – anti-HBx Partially double-stranded DNA (HBV DNA) Very strong resistance Inactivation needs 100℃10’ or 65℃10h Etiology Etiology
HBV 基因型( Genotype) 亚型( Subtype) 准种( Quasispecies 陈佩斯的猫张曼玉的猫崔永元的猫冯巩的猫赵本山的猫周杰伦的猫
Extracellular Rece ptor HBeAg(P18) Intracellula HBsAg(P25, P31, P43) ENDOPLASMIC Endocytosis RETICULUM Fusion 22nm particle plasma membrane HBeAg(P22) NUCLEUS GOLGI Nucleocapsid APPARATUS DNA CO TRANSPORT ESICLE RNA H> 3. 5kb RNA 2. 4kb rNa HBCAg, Pol, HBeAg HBsAg(P43/GP46 2.1kb rna 0.7kb RNA HBsAg(P25/GP28, GP33/GP36) HBV is replicate through reverse transcription
Extracellular Intracellular Endocytosis Fusion with NUCLEUS ENDOPLASMIC RETICULUM GOLGI APPARATUS 3.5kb RNA 2.4kb RNA 0.7kb RNA HBcAg,Pol,HBeAg HBsAg (P43/GP46) HBsAg (P25/GP28,GP33/GP36) HBxAg TRANSPORT VESICLE HBV Nucleocapsid DNA RNA HBeAg (P22) HBeAg(P18) HBsAg (P25,P31,P43) 22nm particle plasma membrane Receptor 2.1kb RNA HBV is replicate through reverse transcription
epidemiology Hepatitis b is a serious public health problem in the world 10 Source of infection acute and chronic patients or chronic "carriers Rout of transmission Parenteral rout(e. g blood maternal-infant.) 10 Susceptibility: l anti-HBs persons (10 Characterizations epidemic in Asia, Africa and Far East higher risk in early childhood
Source of infection: acute and chronic patients, or chronic “carriers” Rout of transmission: Parenteral rout(e.g blood, maternal-infant…) Susceptibility: all anti-HBs (-) persons Characterizations: epidemic in Asia, Africa and Far East higher risk in early childhood Epidemiology Etiology Hepatitis B is a serious public health problem in the world