Pathogenesis ● Host resistance Opportunistic Accidental Innate immunity (protozoa) infections Acquired immunity ● Parasite Invasion Toxin Mechanically damage Immune impair ● Immune inhibition hypersentivity
Pathogenesis • Host Resistance – Innate immunity – Acquired immunity • Parasite Invasion – Toxin – Mechanically damage – Immune impair • Immune inhibition • hypersentivity Opportunistic & Accidental (protozoa) infections
Opportunistic parasites o Opportunistic infection An infection by a microorganism that normally does not cause disease but becomes pathogenic when the body 's immune system is impaired and unable to fight off infection
Opportunistic parasites • Opportunistic infection – An infection by a microorganism that normally does not cause disease but becomes pathogenic when the body's immune system is impaired and unable to fight off infection
Amoebic Infections D Entamoeba histolytica D Acanthamoeba D Naegleria
Entamoeba histolytica Acanthamoeba Naegleria Amoebic Infections
Epidemiology 4th leading cause of death from parasitic diseases worldwide organism of deaths/yr infected Entamoeba 75,000 n300 million Ascaris ~200,000 N480 million Schistosoma 750,000 200 million Plasmodium 2-3 million N500 million (Malaria) Amoebiasis is not restricted to the tropics and subtropics, it also occurs in temperate and even in arctic and antarctic zones
Epidemiology • 4th leading cause of death from parasitic diseases worldwide Organism # of deaths/yr # infected Entamoeba ~75,000 ~300 million Ascaris ~200,000 ~480 million Schistosoma ~750,000 ~200 million Plasmodium 2-3 million ~500 million (Malaria) • Amoebiasis is not restricted to the tropics and subtropics, it also occurs in temperate and even in arctic and antarctic zones
Contaminated water is a source of infection
Contaminated water is a source of infection