第一代分子标记一RFLP RFLP Restriction Fragment Length Polymorphism 限制性片段长度多态性
第一代分子标记---RFLP RFLP: Restriction Fragment Length Polymorphism 限制性片段长度多态性
最早发现的DNA分子标记-RFLP 遗传图- Locus(座位) Site(位点) EcoR1酶切 DNA1 DNA1-1 DNA1-2 IE DNA1-2 物理图-site(位点) Locus(座位)
最早发现的DNA分子标记--RFLP
RFLP是如何想到的? 1978年,在犹他州盐湖城滑雪胜地艾尔 塔的一场例行的学术讨论中,从事经典 人类遗传学研究的专家与从事分子生物 学研究的专家进行学术交流分子生物 学家从经典遗传学的研究中获得灵感 Botstein d. white rl. skolnick m. davis rw
RFLP是如何想到的? 1978年, 在犹他州盐湖城滑雪胜地艾尔 塔的一场例行的学术讨论中, 从事经典 人类遗传学研究的专家与从事分子生物 学研究的专家进行学术交流. 分子生物 学家从经典遗传学的研究中获得灵感. Botstein D, White RL, Skolnick M, Davis RW
David botstein David botstein是首先提出RFLP想法 的科学家 PRINcetoN, N.J. Princeton University has named David botstein, a renowned geneticist, educator and pioneer of the Human Genome Project, as the new director of the lewis-sigler institute for Integrative Genomics. Botstein will succeed Shirley m. tilghman, who was the founding director of the institute and became president of the University in 2001, and james Broach, who is interim director. Botstein's appointment will begin July 1, 2003
David Botstein David Botstein是首先提出RFLP想法 的科学家. PRINCETON, N.J. -- Princeton University has named David Botstein, a renowned geneticist, educator and pioneer of the Human Genome Project, as the new director of the Lewis-Sigler Institute for Integrative Genomics. Botstein will succeed Shirley M. Tilghman, who was the founding director of the institute and became president of the University in 2001, and James Broach, who is interim director. Botstein's appointment will begin July 1, 2003
篇只有想法而无实验的论文 Botstein d. white rl. skolnick m. davis Rw(1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Amj Hum genet 32: 314-331 这是一篇在基因组研究中具有里程碑意义的论文
一篇只有想法而无实验的论文 Botstein D, White RL, Skolnick M, Davis RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 32:314–331 这是一篇在基因组研究中具有里程碑意义的论文