GN:1. Membranous(membranous nephropathy)(1) Most common cause of NS in adults(2)Features:Diffuse thickening of capillary wallImmune complex depositing alongepithelium (subepithelial) side
1. Membranous GN: (membranous nephropathy) (1) Most common cause of NS in adults (2) Features: ▪ Diffuse thickening of capillary wall ▪ Immune complex depositing along epithelium (subepithelial)side
3)EtiologyDPrimarylesion:85%unclearRelated diseases or factorsi Malignant epithelial tumors:carcinoma of lung,colonmelanoma (5-10%).iiChronic hepatitis B, syphilis,malaria, infectious disease
(3) Etiology ① Primary lesion: 85% unclear ② Related diseases or factors: ▪ ⅰ Malignant epithelial tumors: carcinoma of lung , colon melanoma (5-10%) ▪ ⅱ Chronic hepatitis B, syphilis, malaria, infectious disease
.iiiSLE:5-15%-ivExposure to inorganic salts:and metalmercuryDrugs: 1-7% patients withrheumatiodarthritis treatedbypenicillamineviMetabolic disorders:diabites ,thyroiditis
▪ ⅲ SLE:5-15% ▪ ⅳ Exposure to inorganic salts: mercury and metal ▪ ⅴ Drugs: 1-7% patients with rheumatiod arthritis treated by penicillamine ▪ ⅵ Metabolic disorders: diabites , thyroiditis
(4)Pathogenesis@ Chronic immune complex GNanti-glomerularAgautoAbformation ofimmunecomplex and complement in thesubepithelial deposits
(4) Pathogenesis ① Chronic immune complex GN anti-glomerular Ag auto Ab formation of immune complex and complement in the subepithelial deposits
2Genetic susceptibilityis suggested by theincreasedprevalence0f HLA-DR3
② Genetic susceptibility is suggested by the increased prevalence of HLA-DR3