Mechanisms of glomerular injury Immune Non-immnue Glomerular Diseases 6
Glomerular Diseases 6 Mechanisms of glomerular injury Immune Non-immnue
Mechanisms of glomerular injury Immune mechanisms In situ immune-complex deposition Circulating immune complex deposition Cytotoxic antibodies Cell-mediated immunity Activation of alternative complement pathway Glomerular Diseases
Glomerular Diseases 7 Mechanisms of glomerular injury Immune mechanisms ◼ In situ immune-complex deposition ◼ Circulating immune complex deposition ◼ Cytotoxic antibodies ◼ Cell-mediated immunity ◼ Activation of alternative complement pathway
Mechanisms of glomerular injury 1.In situ immune-complex deposition o。量。p云2平oY。 O antigen,Y antibody,immune-complex Glomerular Diseases 8
Glomerular Diseases 8 Mechanisms of glomerular injury ◼ ⒈ In situ immune-complex deposition ○ antigen，Y antibody， immune-complex
Mechanisms of glomerular injury 2.Circulating immune complex deposition 9 O antigen,Y antibody,immune-complex Glomerular Diseases 9
Glomerular Diseases 9 Mechanisms of glomerular injury ◼ ⒉ Circulating immune complex deposition ○ antigen，Y antibody， immune-complex
Mechanisms of glomerular injury 3.Cytotoxic antibodies Abs to glomerular cell Ags cause damage without the formation and deposition of IC. 4.Cell-mediated immunity T cells form cell-mediated immune reactions can cause glomerular injury. 5.Activation of alternative complement pathway Glomerular Diseases 10
Glomerular Diseases 10 Mechanisms of glomerular injury ◼ ⒊ Cytotoxic antibodies Abs to glomerular cell Ags cause damage without the formation and deposition of IC. ◼ ⒋ Cell-mediated immunity T cells form cell-mediated immune reactions can cause glomerular injury. ◼ ⒌ Activation of alternative complement pathway