Risk Factors Inhaled Antigens: the morbidity of asthma is increasing icture by
Risk Factors • Inhaled Antigens： the morbidity of asthma is increasing
Risk Factors New Pathogens and antimicrobial resistance ESBL, MRSA, antimicrobial resistant bacterial Virus non-specITIc pathogens Influenza virus ESB Influenza enters rough the nose and settles in the respiratory tract. Lungs Influenza virus 医院 上海市重点学
Risk Factors • New Pathogens and antimicrobial resistance – ESBL, MRSA, antimicrobial resistant bacterial – Virus – non-specific pathogens ESBL
Physiology Defense Double circulation: pulmonary circulation interposed between the right and left ventricles blood gas exchange production and release humoral mediators a barrier to maintain lung fluid balance bronchial circulation from systemic circulation mostly perfuse the upper airways Pulmonary Arteries and veins provide nutritive flow 中山医院 病研究所 点学剽
• Double Circulation： – pulmonary circulation: interposed between the right and left ventricles blood gas exchange production and release humoral mediators a barrier to maintain lung fluid balance – bronchial circulation: from systemic circulation mostly perfuse the upper airways provide nutritive flow Physiology & Defense
Physiology Defense Defense Mechanisms and Immunology physical barrier: against airbone pathogens and irritants(cough clearance, mucus cytoplasmic cilia) SIZE (diameter) HOST DEFENSES Turbinates AMBIENT AIR 10 ANATOMIC BARRIE ANGULATION OR AIR MICRO-ORGANISMS MUCO-CILIARY Turbulent flow COUGH Airway angulation AIR EXCHANGE SURFACE 05-3p SURFACTANT SONINS-IgG. FIBRONECTIN COMPLEMENT alternate pathway) ALVEOLAR MACROPHAGES 0.5 (stays in gaseous PLASMA COMPONENTS VASO-ACTIVE MEDIATORS大学附属中山医院 科暨呼吸病研究所 上海市重点学
• Defense Mechanisms and Immunology – physical barrier: against airbone pathogens and irritants (cough clearance, mucuscytoplasmic cilia) Physiology & Defense
Physiology Defense Defense Mechanisms and Immunology alveolar clearance(alveolar macrophages PMN, T cell) lmmunology(lgA、lgM、gG) Too strong stimuli and weak defense results in lesion and injury of the lung Asthma COPD ALI infection 复旦大学附属中山医院 呼吸科暨呼吸病研究所 上海市重点学
• Defense Mechanisms and Immunology – alveolar clearance (alveolar macrophages, PMN, T cell) – Immunology (IgA、IgM、IgG) Too strong stimuli and weak defense results in lesion and injury of the lung – Asthma – COPD – ALI – infection Physiology & Defense